Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CD38 | P28907 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11026175 | 0.82 | SLC6A3 (0.40) | ALDH1A1HTTKMT2ASLC6A3MAPT | |
| SCHEMBL13225706 | 0.82 | AKR1B1 (0.45) | ALDH1A1HTTKMT2ASLC6A3MAPT | |
| SCHEMBL13225707 | 0.79 | NPC1 (0.42) | ALDH1A1HTTKMT2AMAPTNPC1 | |
| SCHEMBL22607861 | 0.77 | TRPM8 (0.43) | KMT2AMAPTRAB9AKDM4EPKM | |
| SCHEMBL28981221 | 0.76 | ALOX5 (0.35) | ALDH1A1HTTGSK3BALOX5KDM4E | |
| SCHEMBL23997416 | 0.76 | NPSR1 (0.44) | ALDH1A1HTTKMT2ASLC6A3MAPT | |
| SCHEMBL27658739 | 0.76 | ALDH1A1 (0.43) | ALDH1A1HTTKMT2ASLC6A3MAPT | |
| SCHEMBL13235885 | 0.74 | SLC6A3 (0.39) | ALDH1A1HTTKMT2ASLC6A3MAPT | |
| SCHEMBL5196658 | 0.73 | MAPK8 (0.39) | HTTKMT2ANPC1ALOX5KDM4E | |
| SCHEMBL27615571 | 0.72 | SLC6A3 (0.39) | ALDH1A1HTTKMT2ASLC6A3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008081476-A2 | PROCESS FOR PREPARING DULOXETINE HYDROCHLORIDE | CADILA HEALTHCARE LIMITED (IN) | 2008-07-10 | — | — | WO | claimed |
| WO-2008081476-A2 | PROCESS FOR PREPARING DULOXETINE HYDROCHLORIDE | CADILA HEALTHCARE LIMITED (IN) | 2008-07-10 | — | — | WO | disclosed |