Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | DRD3 | P35462 | 3/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | HTR2B | P41595 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4580935 | 0.89 | OPRM1 (0.44) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL1968862 | 0.89 | LMNA (0.64) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL1973769 | 0.84 | HRH1 (0.47) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL13560828 | 0.80 | HRH1 (0.81) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL16345651 | 0.80 | HRH1 (0.81) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL9075810 | 0.80 | KCNH2 (0.61) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL8680660 | 0.79 | OPRD1 (0.45) | HRH1KCNH2LMNADRD3HTR2A | |
| Hydrochloric Acid SCHEMBL13516884 | 0.79 | HRH1 (0.82) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL8811661 | 0.78 | LMNA (0.59) | HRH1KCNH2LMNADRD3HTR2A | |
| SCHEMBL1969399 | 0.78 | LMNA (0.51) | HRH1KCNH2LMNADRD3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080227983-A1 | PIPERIDINE DERIVATIVES AND PROCESS FOR THEIR PRODUCTION | AMR TECHNOLOGY, INC. (US) | 2008-09-18 | — | — | US | disclosed |
| US-7390906-B2 | Forming ketone intermediates to terfenadine carboxylic acid metabolite; by use of pure regioisomer of 4-(Cyclopropyl-oxo-methyl)-alpha,alpha-dimethylphenylacetic acid | AMR TECHNOLOGY, INC. (US) | 2008-06-24 | — | — | US | disclosed |
| US-7238834-B2 | Piperidine derivatives and process for their production | AMR TECHNOLOGY, INC. (US) | 2007-07-03 | — | — | US | disclosed |
| US-20060241303-A1 | Piperidine derivatives and process for their production | AMR TECHNOLOGY, INC. (US) | 2006-10-26 | — | — | US | disclosed |
| US-7022880-B2 | Piperidine derivatives and process for their production | AMR TECHNOLOGY , INC. (US) | 2006-04-04 | — | — | US | disclosed |
| US-20060052610-A1 | Piperidine derivatives and process for their production | AMR TECHNOLOGY, INC. (US) | 2006-03-09 | — | — | US | disclosed |
| US-20050020628-A1 | Piperidine derivatives and process for their production | AMR TECHNOLOGY, INC. (US) | 2005-01-27 | — | — | US | disclosed |
| US-6797826-B2 | ACYLATING A STARTING COMPOUND CONTAINING CARBOXY OR AMIDE OR ESTER-ISOPROPYLBENZENE COMPOUND WITH AN CHLOROBUTANOYLHALIDE TO FORM MIXTURE OF REGIOISOMER, HYDROLYZING TO FORM SECOND MIXTURE AND RECOVERING SUBSTANTIALLY PURE RGIOISMOR | AMR TECHNOLOGY, INC. | 2004-09-28 | — | — | US | disclosed |
| EP-1369409-A1 | Process for preparing compounds useful as intermediates | ALBANY MOLECULAR RESEARCH, INC. (US) | 2003-12-10 | — | — | EP | disclosed |
| US-20030018196-A1 | Piperidine derivatives and process for their production | BARCLAYS BANK PLC, AS THE COLLATERAL AGENT | 2003-01-23 | — | — | US | disclosed |
| US-5994549-A | Piperidine derivatives and process for their production | ALBANY MOLECULAR RESEARCH, INC. (US) | 1999-11-30 | — | — | US | disclosed |
| EP-0703902-B1 | PROCESS FOR THE PRODUCTION OF PIPERIDINE DERIVATIVES | ALBANY MOLECULAR RES INC (US) | 1998-12-16 | — | — | EP | disclosed |
| US-5663412-A | Aromatic ketones | ALBANY MOLECULAR RESEARCH, INC. (US) | 1997-09-02 | — | — | US | disclosed |
| US-5589487-A | Piperidine derivatives and process for their production | ALBANY MOLECULAR RESEARCH, INC. (US) | 1996-12-31 | — | — | US | disclosed |
| US-5581011-A | Aromatic ketones and processes for their preparation | ALBANY MOLECULAR RESEARCH, INC. (US) | 1996-12-03 | — | — | US | disclosed |
| US-5578610-A | Piperidine derivatives | ALBANY MOLECULAR RESEARCH, INC. (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0723958-A1 | Synthesis of substantially pure terfenadine derivatives | ALBANY MOLECULAR RESEARCH, INC. (US) | 1996-07-31 | — | — | EP | disclosed |
| EP-0703902-A4 | — | ALBANY MOLECULAR RES INC (US) | 1996-04-10 | — | — | EP | disclosed |
| EP-0703902-A1 | PIPERIDINE DERIVATIVES AND PROCESS FOR THEIR PRODUCTION | ALBANY MOLECULAR RESEARCH, INC. (US) | 1996-04-03 | — | — | EP | disclosed |
| WO-1995000482-A1 | PIPERIDINE DERIVATIVES AND PROCESS FOR THEIR PRODUCTION | ALBANY MOLECULAR RESEARCH, INC. (US) | 1995-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030018196-A1 | Piperidine derivatives and process for their production | DRD4, HRH4, DRD2 | HRH1 27/4885KCNH2 204/4885LMNA 4133/4885 |
| US-20060241303-A1 | Piperidine derivatives and process for their production | HRH4, DRD4, H1-4 | HRH1 12/4885KCNH2 178/4885LMNA 4248/4885 |
| US-20060052610-A1 | Piperidine derivatives and process for their production | HRH4, DRD4, H1-4 | HRH1 12/4885KCNH2 178/4885LMNA 4248/4885 |
| US-20080227983-A1 | PIPERIDINE DERIVATIVES AND PROCESS FOR THEIR PRODUCTION | HRH4, DRD4, H1-4 | HRH1 11/4885KCNH2 158/4885LMNA 4278/4885 |
| US-20050020628-A1 | Piperidine derivatives and process for their production | DRD4, HRH4, H1-4 | HRH1 11/4885KCNH2 196/4885LMNA 4276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.