SCHEMBL4580479

SCHEMBL4580479

O=P(O)(O)Oc1cc(Cl)ccc1Cl

nearest known ligand 0.52

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
INPPL1 O15357 11/20 0.52
INPP5A Q14642 6/20 0.52
INPP5B P32019 2/20 0.52
AKT1 P31749 1/20 0.47
ALDH1A1 P00352 2/20 0.40
CYP3A4 P08684 1/20 0.40
TSHR P16473 1/20 0.40
HSD17B10 Q99714 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
GGPS1 O95749 1/20 0.40
CA1 P00915 1/20 0.40
CA14 Q9ULX7 1/20 0.40
TP53 P04637 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6057570 0.88 ALDH1A1 (0.40) ALDH1A1CYP3A4TSHRHSD17B10TDP1
SCHEMBL4372630 0.84 INPPL1 (0.52) INPPL1INPP5AINPP5BAKT1TSHR
SCHEMBL5983682 0.83 TP53 (0.42) ALDH1A1CYP3A4TSHRHSD17B10TDP1
SCHEMBL2987764 0.82 TP53 (0.41) ALDH1A1CYP3A4TSHRHSD17B10TDP1
SCHEMBL27358799 0.81 INPPL1 (0.48) INPPL1INPP5AINPP5BAKT1ALDH1A1
SCHEMBL121443 0.80 TTR (0.54) INPPL1INPP5AINPP5BAKT1ALDH1A1
SCHEMBL8462654 0.78 INPPL1 (0.45) INPPL1INPP5AINPP5BAKT1ALDH1A1
SCHEMBL8460380 0.78 INPPL1 (0.45) INPPL1INPP5AINPP5BAKT1ALDH1A1
SCHEMBL4333883 0.78 INPPL1 (0.45) INPPL1INPP5AINPP5BAKT1ALDH1A1
SCHEMBL13342841 0.77 TSHR (0.50) INPPL1INPP5AINPP5BAKT1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6107039-A MIXING SAMPLE OF NUCLEIC ACID SEQUENCE TO BE ANALYZED WITH OLIGONUCLEOTIDE PROBE CONTAINING AT LEAST ONE THIOL-PROTECTED PYRIMIDINE NUCLEOTIDE, EXPOSING TO ENDONUCLEASE, AND IDENTIFYING FRAGMENTS HAVING HYBRIDIZED PROBE THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA 2000-08-22 US claimed
US-6008334-A MODIFIED PYRIMIDINE NUCLEOSIDES/NUCLEOTIDES WITH PROTECTED THIOL GROUP ATTACHED AT 5 POSITION OF BASE THAT IS NOT INVOLVED IN WATSON-CRICK BASE PARING; FOR USE IN CHEMICAL AND ENZYMATIC SYNTHESIS OF NUCLEIC ACIDS THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) 1999-12-28 US claimed
US-20230096149-A1 Reagents Useful for Synthesizing Rhodamine-Labeled Oligonucleotides APPLIED BIOSYSTEMS, LLC (US) 2023-03-30 US disclosed
US-20220380845-A1 Asymmetric Rhodamine Dye and Use Thereof in Biological Assays Life Technologies Corporation 2022-12-01 US disclosed
US-20220056041-A1 Modified Rhodamine Dye and use Thereof in Biological Assays Life Technologies Corporation 2022-02-24 US disclosed
EP-3898842-A1 MODIFIED RHODAMINE DYE AND USE THEREOF IN BIOLOGICAL ASSAYS Life Technologies Corporation (US) 2021-10-27 EP disclosed
EP-3898841-A1 ASYMMETRIC RHODAMINE DYE AND USE THEREOF IN BIOLOGICAL ASSAYS Life Technologies Corporation (US) 2021-10-27 EP disclosed
WO-2020132607-A9 ASYMMETRIC RHODAMINE DYE AND USE THEREOF IN BIOLOGICAL ASSAYS Life Technologies Corporation (US) 2020-11-26 WO disclosed
US-20200270287-A1 Reagents Useful for Synthesizing Rhodamine-Labeled Oligonucleotides APPLIED BIOSYSTEMS, LLC (US) 2020-08-27 US disclosed
WO-2020132487-A1 MODIFIED RHODAMINE DYE AND USE THEREOF IN BIOLOGICAL ASSAYS Life Technologies Corporation (US) 2020-06-25 WO disclosed
WO-2020132607-A1 ASYMMETRIC RHODAMINE DYE AND USE THEREOF IN BIOLOGICAL ASSAYS Life Technologies Corporation (US) 2020-06-25 WO disclosed
EP-2001871-A2 REAGENTS USEFUL FOR SYNTHESIZING RHODAMINE-LABELED OLIGONUCLEOTIDES APPLIED BIOSYSTEMS, INC. (US) 2008-12-17 EP disclosed
US-20080071070-A1 Coupling with phosphoramidite reagent; solid phase synthesis APPLERA CORPORATION (US) 2008-03-20 US disclosed
US-20070292733-A1 Binder for Fuel Cell, Composition for Forming Electrode, Electrode, and Fuel Cell Using the Electrode MITSUI CHEMICALS, INC. (JP) 2007-12-20 US disclosed
WO-2007115265-A9 REAGENTS USEFUL FOR SYNTHESIZING RHODAMINE-LABELED OLIGONUCLEOTIDES APPLERA CORP (US) 2007-11-29 WO disclosed
WO-2007115265-A2 REAGENTS USEFUL FOR SYNTHESIZING RHODAMINE-LABELED OLIGONUCLEOTIDES APPLIED BIOSYSTEMS INC. (US) 2007-10-11 WO disclosed
EP-1788649-A1 BINDER FOR FUEL CELL, COMPOSITION FOR ELECTRODE FORMATION, ELECTRODE, AND FUEL CELL USING THE ELECTRODE Mitsui Chemicals, Inc. (JP) 2007-05-23 EP disclosed
EP-1664341-A2 SIZE-CONTROLLED MACROMOLECULE Posco (KR) 2006-06-07 EP disclosed
WO-2005026191-A2 SIZE-CONTROLLED MACROMOLECULE POSCO (KR) 2005-03-24 WO disclosed
US-20050037413-A1 functionalized substrates bound to layers of dendrimers and to target-specific ligands, used in combinatorial chemistry, protein, nucleic acid or nucleic acid/peptide hybridization detection; medical diagnosis POSCO (KR) 2005-02-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220056041-A1 Modified Rhodamine Dye and use Thereof in Biological Assays QTRT1, MRPL21, RRP1B INPPL1 2788/4885INPP5A 2414/4885INPP5B 3800/4885
US-20080071070-A1 Coupling with phosphoramidite reagent; solid phase synthesis RTCB, RNGTT, PHAX INPPL1 1401/4885INPP5A 2087/4885INPP5B 1125/4885
US-20220380845-A1 Asymmetric Rhodamine Dye and Use Thereof in Biological Assays HNRNPR, RNASEH1, HNRNPH3 INPPL1 2442/4885INPP5A 3784/4885INPP5B 4005/4885
US-20200270287-A1 Reagents Useful for Synthesizing Rhodamine-Labeled Oligonucleotides RTCB, RRM2B, SNRPE INPPL1 2270/4885INPP5A 3157/4885INPP5B 2433/4885
US-20230096149-A1 Reagents Useful for Synthesizing Rhodamine-Labeled Oligonucleotides RTCB, RRM2B, SNRPE INPPL1 2270/4885INPP5A 3157/4885INPP5B 2433/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.