Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | APAF1 | O14727 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.31 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL120459 | 0.89 | SMN1; SMN2 (0.40) | SMN1; SMN2L3MBTL1ALDH1A1MAPTHPGD | |
| SCHEMBL6129238 | 0.87 | SMN1; SMN2 (0.43) | SMN1; SMN2L3MBTL1ALDH1A1MAPTHPGD | |
| SCHEMBL1396725 | 0.76 | — | — | |
| SCHEMBL24415283 | 0.72 | SMN1; SMN2 (0.46) | SMN1; SMN2L3MBTL1ALDH1A1MAPTHPGD | |
| SCHEMBL30738875 | 0.71 | TRIM24 (0.35) | SMN1; SMN2ALDH1A1TSHRGAA | |
| SCHEMBL6129223 | 0.69 | MAPT (0.44) | SMN1; SMN2HTTL3MBTL1ALDH1A1MAPT | |
| SCHEMBL10446742 | 0.69 | APAF1 (0.39) | SMN1; SMN2HTTL3MBTL1ALDH1A1MAPT | |
| Butane SCHEMBL7750589 | 0.68 | GAA (0.41) | HTTTSHRGAA | |
| SCHEMBL1674760 | 0.68 | SMN1; SMN2 (0.50) | SMN1; SMN2L3MBTL1ALDH1A1MAPTHPGD | |
| SCHEMBL469465 | 0.68 | TYR (0.43) | SMN1; SMN2L3MBTL1ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008049651-A1 | PERFORMANCE-ENHANCED COSMETIC COMPOSITIONS WITH PURINE AND/OR PURINE DERIVATIVES | HENKEL AG & CO. KGAA (DE) | 2008-05-02 | — | — | WO | claimed |
| EP-1880705-A2 | Brightening and/or colouring composition with improved product sensation | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2008-01-23 | — | — | EP | claimed |
| US-20050000529-A1 | Method and compositions for imparting cooling effect to tobacco products | VECTOR TOBACCO INC. | 2005-01-06 | — | — | US | claimed |
| EP-1455609-A2 | METHOD AND COMPOSITIONS FOR IMPARTING COOLING EFFECT TO TOBACCO PRODUCTS | Vector Tobacco Inc. (US) | 2004-09-15 | — | — | EP | claimed |
| US-20040052828-A1 | Consumable product including consumable component and alpha-keto enamine derivatives | NESTEC S.A. (CH) | 2004-03-18 | — | — | US | claimed |
| WO-2003053176-A2 | METHOD AND COMPOSITIONS FOR IMPARTING COOLING EFFECT TO TOBACCO PRODUCTS | VECTOR TOBACCO INC. (US) | 2003-07-03 | — | — | WO | claimed |
| US-20020022039-A1 | Method of using alpha-keto enamine derivatives as ingredients and products incorporating same | NESTEC S.A. (CH) | 2002-02-21 | — | — | US | claimed |
| WO-2008049651-A1 | PERFORMANCE-ENHANCED COSMETIC COMPOSITIONS WITH PURINE AND/OR PURINE DERIVATIVES | HENKEL AG & CO. KGAA (DE) | 2008-05-02 | — | — | WO | disclosed |
| EP-1880705-A2 | Brightening and/or colouring composition with improved product sensation | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2008-01-23 | — | — | EP | disclosed |
| US-20050000529-A1 | Method and compositions for imparting cooling effect to tobacco products | VECTOR TOBACCO INC. | 2005-01-06 | — | — | US | disclosed |
| EP-1455609-A2 | METHOD AND COMPOSITIONS FOR IMPARTING COOLING EFFECT TO TOBACCO PRODUCTS | Vector Tobacco Inc. (US) | 2004-09-15 | — | — | EP | disclosed |
| US-20040086476-A1 | Anti-dandruff and anti-itch compositions containing sensate and sensate enhancer-containing compounds | INTERNATIONAL FLAVORS & FRAGRANCES INC. | 2004-05-06 | — | — | US | disclosed |
| US-20040052828-A1 | Consumable product including consumable component and alpha-keto enamine derivatives | NESTEC S.A. (CH) | 2004-03-18 | — | — | US | disclosed |
| US-20030161802-A1 | Anti-dandruff and anti-itch compositions containing sensate and sensate enhancer-containing compounds | INTERNATIONAL FLAVORS & FRAGRANCES INC. | 2003-08-28 | — | — | US | disclosed |
| EP-1332772-A2 | Anti-dandruff and anti-itch compositions containing a cooling sensate material and a cooling sensate enhancer | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2003-08-06 | — | — | EP | disclosed |
| US-6592884-B2 | Food, cosmetics, drugs; cooling skin, mouth | NESTEC S.A. (CH) | 2003-07-15 | — | — | US | disclosed |
| WO-2003053176-A2 | METHOD AND COMPOSITIONS FOR IMPARTING COOLING EFFECT TO TOBACCO PRODUCTS | VECTOR TOBACCO INC. (US) | 2003-07-03 | — | — | WO | disclosed |
| US-20020022039-A1 | Method of using alpha-keto enamine derivatives as ingredients and products incorporating same | NESTEC S.A. (CH) | 2002-02-21 | — | — | US | disclosed |
| EP-1157617-A2 | Use of alpha-keto enamine derivatives as ingredients | Société des Produits Nestlé S.A. (CH) | 2001-11-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040052828-A1 | Consumable product including consumable component and alpha-keto enamine derivatives | PKN2, OPRD1, PKN1 | SMN1; SMN2 2021/4885HTT 2599/4885L3MBTL1 3770/4885 |
| US-20020022039-A1 | Method of using alpha-keto enamine derivatives as ingredients and products incorporating same | ECH1, KMO, PKN1 | SMN1; SMN2 3101/4885HTT 2330/4885L3MBTL1 3305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.