Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | VDR | P11473 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25403099 | 0.91 | ALDH1A1 (0.45) | PKMDHODHALDH1A1STAT3MAPK1 | |
| SCHEMBL11084685 | 0.90 | CYP1A2 (0.41) | PKMCYP2D6SMN1; SMN2LMNACYP3A4 | |
| SCHEMBL26286109 | 0.87 | CCR5 (0.44) | PKMDHODHALDH1A1STAT3MAPK1 | |
| SCHEMBL26662184 | 0.86 | KMT2A (0.40) | ALDH1A1STAT3HTTLMNA | |
| SCHEMBL26120686 | 0.86 | KMT2A (0.40) | DHODHALDH1A1STAT3MAPK1SMN1; SMN2 | |
| SCHEMBL19725071 | 0.84 | CA2 (0.44) | PKMALDH1A1LMNACYP3A4 | |
| SCHEMBL23624813 | 0.83 | ALDH1A1 (0.40) | PKMDHODHALDH1A1STAT3MAPK1 | |
| SCHEMBL4432214 | 0.83 | CA12 (0.46) | PKMDHODHALDH1A1STAT3MAPK1 | |
| SCHEMBL1206501 | 0.82 | PKM (0.53) | PKMDHODHALDH1A1STAT3MAPK1 | |
| SCHEMBL2545829 | 0.82 | PKM (0.53) | PKMDHODHALDH1A1STAT3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |