Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31535175 | 0.96 | YAP1 (0.50) | YAP1KDM4EALDH1A1ALOX15OPRK1 | |
| SCHEMBL15566591 | 0.93 | ABCG2 (0.47) | YAP1KDM4EALDH1A1OPRK1ABCG2 | |
| SCHEMBL22097620 | 0.84 | ALDH1A1 (0.60) | YAP1KDM4EALDH1A1ALOX15HDAC8 | |
| SCHEMBL4584443 | 0.84 | CA1 (0.50) | KDM4EALDH1A1OPRK1HDAC8HPGD | |
| SCHEMBL22097638 | 0.83 | ALDH1A1 (0.62) | YAP1KDM4EALDH1A1ALOX15HPGD | |
| SCHEMBL13276681 | 0.82 | YAP1 (0.54) | YAP1KDM4EOPRK1HDAC8KMT2A | |
| SCHEMBL28525633 | 0.82 | YAP1 (0.51) | YAP1KDM4EOPRK1 | |
| SCHEMBL8833932 | 0.82 | YAP1 (0.62) | YAP1KDM4EALDH1A1ALOX15OPRK1 | |
| SCHEMBL13276979 | 0.81 | YAP1 (0.52) | YAP1KDM4EALDH1A1OPRK1HDAC8 | |
| SCHEMBL19335455 | 0.80 | KDM4E (0.70) | YAP1KDM4EALDH1A1ALOX15RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100582088-C | Aminoalcohol derivatives | ASTELLAS PHARMA INC | 2010-01-20 | — | — | CN | disclosed |
| US-7417060-B2 | Aminoalcohol derivatives | ASTELLAS PHARMA INC. (JP) | 2008-08-26 | — | — | US | disclosed |
| CN-1906154-A | Aminoalcohol derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 2007-01-31 | — | — | CN | disclosed |
| EP-1697301-A2 | AMINOALCOHOL DERIVATIVES | Astellas Pharma Inc. (JP) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005061433-A2 | AMINOALCOHOL DERIVATIVES | ASTELLAS PHARMA INC. (JP) | 2005-07-07 | — | — | WO | disclosed |
| US-20050137236-A1 | Aminoalcohol derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2005-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137236-A1 | Aminoalcohol derivatives | GPR39, PRMT9, CHRM2 | YAP1 2045/4885KDM4E 1697/4885ALDH1A1 1621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.