Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 11/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 5/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | UBE2M | P61081 | 1/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4586717 | 0.92 | CCR5 (0.50) | CCR5DRD2DRD3PTGER4PGR | |
| SCHEMBL4585297 | 0.90 | CCR5 (0.48) | CCR5DRD2DRD3UBE2MDCUN1D1 | |
| SCHEMBL4586226 | 0.88 | CCR5 (0.50) | CCR5DRD2DRD3PTGER4DCUN1D1 | |
| SCHEMBL4586072 | 0.87 | CCR5 (0.57) | CCR5DRD2DRD3UBE2MDCUN1D1 | |
| SCHEMBL4586088 | 0.86 | CCR5 (0.42) | CCR5DRD2DRD3PGR | |
| SCHEMBL4585482 | 0.83 | CCR5 (0.51) | CCR5DRD2DRD3PGRDCUN1D1 | |
| SCHEMBL4586422 | 0.83 | CCR5 (0.47) | CCR5DRD2DRD3UBE2MDCUN1D1 | |
| SCHEMBL4245568 | 0.82 | CCR5 (0.70) | CCR5 | |
| SCHEMBL4585572 | 0.82 | CCR5 (0.52) | CCR5DRD2DRD3UBE2MDCUN1D1 | |
| SCHEMBL4586981 | 0.80 | CCR5 (0.49) | CCR5DRD2DRD3PTGER4DCUN1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1708703-A4 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC (CA) | 2008-04-09 | — | — | EP | disclosed |
| EP-1708703-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005059107-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | ANORMED INC. (CA) | 2005-06-30 | — | — | WO | disclosed |