Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.36 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | ALDH1A3 | P47895 | 4/20 | 0.36 |
| ▸ | ALDH3A1 | P30838 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4586790 | 0.83 | ALDH1A3 (0.39) | ALDH1A3ALDH3A1ALDH1A1GAAHDAC1 | |
| SCHEMBL29846618 | 0.77 | LMNA (0.50) | KCNH2LTB4RTLR8GPBAR1 | |
| SCHEMBL28187202 | 0.76 | KCNH2 (0.50) | KCNH2LTB4RTLR8 | |
| SCHEMBL27139099 | 0.76 | HDAC1 (0.40) | ALDH1A1GAAHDAC1HDAC2CYSLTR2 | |
| SCHEMBL24219776 | 0.76 | HDAC1 (0.36) | ALDH1A3ALDH3A1ALDH1A1GAAHDAC1 | |
| SCHEMBL181524 | 0.74 | PLA2G4A (0.51) | PLA2G4AALDH1A1HIF1A | |
| SCHEMBL30166116 | 0.73 | CA2 (0.50) | KCNH2LTB4RTLR8PLA2G4AALDH1A1 | |
| SCHEMBL16901825 | 0.73 | KCNH2 (0.46) | KCNH2PLA2G4AALDH1A3ALDH3A1ALDH1A1 | |
| SCHEMBL860157 | 0.73 | KCNH2 (0.58) | KCNH2TLR8GPBAR1ALDH1A1HIF1A | |
| SCHEMBL27148937 | 0.72 | HDAC1 (0.36) | GPBAR1ALDH1A3ALDH1A1GAAHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214455-A1 | Novel Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-09-04 | — | — | US | disclosed |
| EP-1879563-A4 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-07-16 | — | — | EP | disclosed |
| EP-1879563-A2 | NOVEL CHEMICAL COMPOUNDS | Smithkline Beecham Corporation (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006132739-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214455-A1 | Novel Chemical Compounds | HIPK3, HIPK1, HIPK4 | KCNH2 4256/4885LTB4R 4451/4885TLR8 4722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.