SCHEMBL458709

SCHEMBL458709

C=CC(N)c1cncnc1

nearest known ligand 0.34

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15885620 0.74 CYP19A1 (0.33) CYP19A1
SCHEMBL9312689 0.74 CFTR (0.48) CYP19A1
SCHEMBL3408213 0.71 SLC6A2 (0.39) CYP19A1
SCHEMBL6291617 0.71 ADRB2 (0.31)
SCHEMBL28090653 0.71
SCHEMBL2558527 0.70 AKT1 (0.31)
SCHEMBL2557345 0.70 AKT1 (0.31)
SCHEMBL4313822 0.67
SCHEMBL8657854 0.67
SCHEMBL28244867 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011128374-A1 INSULIN-SIRNA CONJUGATES SANOFI (FR) 2011-10-20 WO claimed
US-11707483-B2 Micellic assemblies UNIVERSITY OF WASHINGTON (US) 2023-07-25 US disclosed
US-20200147121-A1 MICELLIC ASSEMBLIES UNIVERSITY OF WASHINGTON (US) 2020-05-14 US disclosed
US-10420790-B2 Micellic assemblies UNIVERSITY OF WASHINGTON (US) 2019-09-24 US disclosed
US-10195284-B2 Compositions and methods for controlled localized delivery of bone forming therapeutic agents UNIVERSITY OF ROCHESTER (US) 2019-02-05 US disclosed
US-10066043-B2 ω-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization UNIVERSITY OF WASHINGTON (US) 2018-09-04 US disclosed
US-9949950-B2 Compositions and methods for controlled localized delivery of bone forming therapeutic agents UNIVERSITY OF ROCHESTER (US) 2018-04-24 US disclosed
US-20170239360-A1 MICELLIC ASSEMBLIES UNIVERSITY OF WASHINGTON (US) 2017-08-24 US disclosed
US-9662403-B2 Micellic assemblies UNIVERSITY OF WASHINGTON (US) 2017-05-30 US disclosed
US-20170145141-A1 OMEGA-FUNCTIONALIZED POLYMERS, JUNCTION-FUNCTIONALIZED BLOCK COPOLYMERS, POLYMER BIOCONJUGATES, AND RADICAL CHAIN EXTENSION POLYMERIZATION UNIVERSITY OF WASHINGTON (US) 2017-05-25 US disclosed
EP-2296627-A2 MICELLES FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS The University of Washington (US) 2011-03-23 EP disclosed
EP-2285853-A2 MICELLIC ASSEMBLIES University of Washington (US) 2011-02-23 EP disclosed
WO-2010077678-A2 OMEGA-FUNCTIONALIZED POLYMERS, JUNCTION-FUNCTIONALIZED BLOCK COPOLYMERS, POLYMER BIOCONJUGATES, AND RADICAL CHAIN EXTENSION POLYMERIZATION UNIVERSITY OF WASHINGTON (US) 2010-07-08 WO disclosed
WO-2010053597-A2 MICELLES OF HYDROPHILICALLY SHIELDED MEMBRANE-DESTABILIZING COPOLYMERS UNIVERSITY OF WASHINGTON/////////////////////-+ (US) 2010-05-14 WO disclosed
WO-2010021770-A1 HETEROGENEOUS POLYMERIC MICELLES FOR INTRACELLULAR DELIVERY UNIVERSITY OF WASHINGTON (US) 2010-02-25 WO disclosed
WO-2009140432-A2 MICELLES FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS UNIVERSITY OF WASHINGTON (US) 2009-11-19 WO disclosed
WO-2009140429-A2 MICELLIC ASSEMBLIES UNIVERSITY OF WASHINGTON (US) 2009-11-19 WO disclosed
WO-2009140423-A2 TARGETED POLYMER BIOCONJUGATES UNIVERSITY OF WASHINGTON (US) 2009-11-19 WO disclosed
WO-2009140421-A2 POLYMERIC CARRIER UNIVERSITY OF WASHINGTON (US) 2009-11-19 WO disclosed
CN-101437943-A Antisense agents combining strongly bound base - modified oligonucleotide and artificial nuclease BALTIC TECHNOLOGY DEV LTD (EE) 2009-05-20 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11707483-B2 Micellic assemblies UACA, CLPTM1L, BPHL CYP19A1 4822/4885
US-10420790-B2 Micellic assemblies UACA, CLPTM1L, BPHL CYP19A1 4822/4885
US-20200147121-A1 MICELLIC ASSEMBLIES CLPX, VCL, ANXA5 CYP19A1 4803/4885
US-20170239360-A1 MICELLIC ASSEMBLIES UACA, CLPTM1L, BPHL CYP19A1 4822/4885
US-10066043-B2 ω-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization FASN, ALOX5, FGB CYP19A1 3529/4885
US-20170145141-A1 OMEGA-FUNCTIONALIZED POLYMERS, JUNCTION-FUNCTIONALIZED BLOCK COPOLYMERS, POLYMER BIOCONJUGATES, AND RADICAL CHAIN EXTENSION POLYMERIZATION FASN, ALOX5, ELOVL3 CYP19A1 3426/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.