Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 14/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573939 | 0.92 | SLC6A9 (0.48) | SLC6A9KCNH2AOC3CTSBCTSS | |
| SCHEMBL4573200 | 0.79 | CTSK (0.57) | SLC6A9KCNH2CTSBCTSSCTSK | |
| SCHEMBL4586118 | 0.78 | CTSB (0.42) | KCNH2CTSBCTSSCTSK | |
| SCHEMBL4589748 | 0.77 | CTSB (0.54) | SLC6A9KCNH2AOC3CTSBCTSS | |
| SCHEMBL8108173 | 0.76 | CTSB (0.65) | KCNH2CTSBCTSSCTSK | |
| SCHEMBL4573950 | 0.76 | CTSS (0.45) | KCNH2KMT2ACTSBCTSSCTSK | |
| SCHEMBL4790305 | 0.71 | USP30 (0.41) | KMT2ACTSBCTSSCTSK | |
| SCHEMBL4573253 | 0.71 | CTSK (0.39) | KCNH2KMT2AMEN1CTSBCTSS | |
| SCHEMBL4573015 | 0.71 | CTSK (0.38) | KCNH2KMT2AMEN1CTSBCTSS | |
| SCHEMBL4572944 | 0.68 | ALDH1A1 (0.39) | KCNH2LMNACTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |