Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31472982 | 1.00 | ALDH1A1 (0.47) | ALDH1A1KDM4EPKMHPGDHSD17B10 | |
| SCHEMBL28230962 | 0.84 | ESR1 (0.38) | ALDH1A1KDM4EPKMHPGDHSD17B10 | |
| SCHEMBL3556000 | 0.83 | IDO1 (0.44) | ALDH1A1KDM4EPKMHPGDHSD17B10 | |
| SCHEMBL14367955 | 0.83 | ALDH1A1 (0.52) | ALDH1A1KDM4EPKMHPGDHSD17B10 | |
| SCHEMBL31706466 | 0.82 | IDO1 (0.43) | ALDH1A1KDM4EPKMHPGDHSD17B10 | |
| SCHEMBL5102965 | 0.82 | ALDH1A1 (0.50) | ALDH1A1KDM4EPKMHPGDHSD17B10 | |
| SCHEMBL5918421 | 0.82 | ALDH1A1 (0.46) | ALDH1A1KDM4EPKMHPGDHSD17B10 | |
| SCHEMBL13202273 | 0.81 | TAAR1 (0.44) | ALDH1A1KDM4EPKMHPGDHSD17B10 | |
| SCHEMBL28097878 | 0.81 | AOC1 (0.32) | ALDH1A1KDM4EPKMHPGDHSD17B10 | |
| SCHEMBL27721574 | 0.81 | NR1H2 (0.41) | ALDH1A1KDM4EHPGDHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115925642-B | Synthesis method of 1, 4-benzodiazepine Zhuo Zahuan derivative | 枣庄学院 | 2025-02-07 | — | — | CN | disclosed |
| CN-115925642-A | Synthesis method of 1, 4-benzodiazepine heterocyclic derivative | 枣庄学院 | 2023-04-07 | — | — | CN | disclosed |
| CN-111925334-B | Synthetic method of 5H-1, 4-benzodiazepine compound | 扬州大学 | 2021-11-23 | — | — | CN | disclosed |
| CN-111925334-A | Synthetic method of 5H-1, 4-benzodiazepine compound | 扬州大学 | 2020-11-13 | — | — | CN | disclosed |
| CN-101155787-B | (3,4-dihydro-quinazolin-2-yl)-indan-1-yl-amines | HOFFMANN LA ROCHE | 2010-11-24 | — | — | CN | disclosed |
| CN-101155787-A | (3,4-dihydro-quinazolin-2-yl)-indan-1-yl-amines | HOFFMANN LA ROCHE (CH) | 2008-04-02 | — | — | CN | disclosed |
| US-7348332-B2 | (3,4-dihydro-quinazolin-2-yl)-indan-1-yl-amines | HOFFMANN-LA ROCHSE INC. (US) | 2008-03-25 | — | — | US | disclosed |
| US-7348332-B2 | (3,4-dihydro-quinazolin-2-yl)-indan-1-yl-amines | HOFFMANN-LA ROCHSE INC. (US) | 2008-03-25 | — | — | US | disclosed |
| US-7348332-B2 | (3,4-dihydro-quinazolin-2-yl)-indan-1-yl-amines | HOFFMANN-LA ROCHSE INC. (US) | 2008-03-25 | — | — | US | disclosed |
| EP-1871748-A1 | (3,4-DIHYDRO-QUINAZOLIN-2-YL)-INDAN-1-YL-AMINES | F. Hoffmann-Roche AG (CH) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006108773-A1 | (3,4-DIHYDRO-QUINAZOLIN-2-YL)-INDAN-1-YL-AMINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-10-19 | — | — | WO | disclosed |
| US-20060229323-A1 | (3,4-Dihydro-quinazolin-2-yl)-indan-1-yl-amines | F. HOFFMANN-LA ROCHE AG (CH) | 2006-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060229323-A1 | (3,4-Dihydro-quinazolin-2-yl)-indan-1-yl-amines | HTR5A, HTR1A, HTR1E | ALDH1A1 281/4885KDM4E 928/4885PKM 3499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.