Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15249282 | 0.95 | TSHR (0.39) | TSHRHPGDALDH1A1CYP3A4TP53 | |
| SCHEMBL411497 | 0.95 | TSHR (0.41) | TSHRHPGDALDH1A1CYP3A4TP53 | |
| SCHEMBL12588621 | 0.95 | TSHR (0.41) | TSHRHPGDALDH1A1CYP3A4TP53 | |
| SCHEMBL12131518 | 0.90 | TSHR (0.41) | TSHRHPGDALDH1A1CYP3A4TP53 | |
| SCHEMBL30280708 | 0.90 | TSHR (0.42) | TSHRHPGDALDH1A1CYP3A4TP53 | |
| SCHEMBL26310564 | 0.89 | TSHR (0.36) | TSHRHPGDALDH1A1CYP3A4TP53 | |
| SCHEMBL411296 | 0.86 | TSHR (0.41) | TSHRHPGDALDH1A1CYP3A4TP53 | |
| SCHEMBL410909 | 0.86 | TSHR (0.41) | TSHRHPGDALDH1A1CYP3A4TP53 | |
| SCHEMBL12094888 | 0.85 | LPAR5 (0.31) | LPAR5 | |
| SCHEMBL13230685 | 0.83 | TSHR (0.50) | TSHRHPGDALDH1A1CYP3A4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228466-A1 | TRANSITION METAL COMPLEXES AS VISIBLE LIGHT ABSORBERS | JOHNSON & JOHNSON VISION CARE, INC. | 2024-07-11 | — | — | US | disclosed |
| US-11971518-B2 | Shape engineering of particles to create a narrow spectral filter against a specific portion of the light spectrum | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2024-04-30 | — | — | US | disclosed |
| US-20240067825-A1 | POLYMERIZABLE ABSORBERS OF UV AND HIGH ENERGY VISIBLE LIGHT | JOHNSON & JOHNSON VISION CARE (US) | 2024-02-29 | — | — | US | disclosed |
| US-20240067622-A1 | PHOTOSTABLE MIMICS OF MACULAR PIGMENT | JOHNSON & JOHNSON VISION CARE (US) | 2024-02-29 | — | — | US | disclosed |
| US-11912800-B2 | Amide-functionalized polymerization initiators and their use in the manufacture of ophthalmic lenses | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-20240018294-A1 | OPHTHALMIC DEVICES DERIVED FROM GRAFTED POLYMERIC NETWORKS AND PROCESSES FOR THEIR PREPARATION AND USE | JOHNSON & JOHNSON VISION CARE (US) | 2024-01-18 | — | — | US | disclosed |
| US-11829008-B2 | Increased stiffness center optic in soft contact lenses for astigmatism correction | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2023-11-28 | — | — | US | disclosed |
| US-11827755-B2 | Silicone hydrogel contact lenses having non-uniform morphology | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2023-11-28 | — | — | US | disclosed |
| US-11820899-B2 | Polymerizable absorbers of UV and high energy visible light | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2023-11-21 | — | — | US | disclosed |
| US-11820850-B2 | Polymer compositions containing grafted polymeric networks and processes for their preparation and use | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2023-11-21 | — | — | US | disclosed |
| US-20100133710-A1 | BIOMEDICAL DEVICES CONTAINING INTERNAL WETTING AGENTS | JOHNSON & JOHNSON VISION CARE, INC. | 2010-06-03 | — | — | US | disclosed |
| US-20100084775-A1 | BIOMEDICAL DEVICES CONTAINING INTERNAL WETTING AGENTS | JOHNSON & JOHNSON VISION CARE, INC. | 2010-04-08 | — | — | US | disclosed |
| US-7691916-B2 | Biomedical devices containing internal wetting agents | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2010-04-06 | — | — | US | disclosed |
| US-7666921-B2 | Contact lenses for extended wear (without surface treatment, coating-free), formed by reacting polyvinylpyrrolidone and (2-methacryloxy-3-hydroxypropyloxy)propylbis(trimethylsiloxy) methylsilane, then curing | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2010-02-23 | — | — | US | disclosed |
| US-7649058-B2 | Biomedical devices containing internal wetting agents | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2010-01-19 | — | — | US | disclosed |
| US-20080316424-A1 | Biomedical Devices Containing Internal Wetting Agents | JOHNSON & JOHNSON VISION CARE, INC. | 2008-12-25 | — | — | US | disclosed |
| US-7368589-B2 | Purification of silicone containing compounds by supercritical fluid extraction | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2008-05-06 | — | — | US | disclosed |
| US-20080015282-A1 | BIOMEDICAL DEVICES CONTAINING INTERNAL WETTING AGENTS | JOHNSON & JOHNSON VISION CARE, INC. | 2008-01-17 | — | — | US | disclosed |
| US-20070242219-A1 | FACILITATING RELEASE OF SILICONE HYDROGEL OPHTHALMIC LENSES | JOHNSON & JOHNSON VISION CARE, INC. | 2007-10-18 | — | — | US | disclosed |
| US-20070229757-A1 | BIOMEDICAL DEVICES CONTAINING INTERNAL WETTING AGENTS | JOHNSON & JOHNSON VISION CARE, INC. | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240067622-A1 | PHOTOSTABLE MIMICS OF MACULAR PIGMENT | CRY1, PDE6C, PDE6A | TSHR 2804/4885HPGD 1412/4885ALDH1A1 2396/4885 |
| US-11912800-B2 | Amide-functionalized polymerization initiators and their use in the manufacture of ophthalmic lenses | CRYAA, UACA, CRYAB | TSHR 1161/4885HPGD 2045/4885ALDH1A1 1469/4885 |
| US-20240228466-A1 | TRANSITION METAL COMPLEXES AS VISIBLE LIGHT ABSORBERS | UACA, C1R, MSH2 | TSHR 605/4885HPGD 851/4885ALDH1A1 333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.