Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9973557 | 0.95 | TSHR (0.37) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL411296 | 0.90 | TSHR (0.41) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL411497 | 0.90 | TSHR (0.41) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL459135 | 0.86 | TSHR (0.42) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL1284119 | 0.86 | ATM (0.31) | LPAR5 | |
| SCHEMBL12588621 | 0.84 | TSHR (0.41) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL31299545 | 0.84 | TSHR (0.44) | TSHRHPGDALDH1A1CYP3A4LPAR5 | |
| SCHEMBL35419 | 0.83 | USP2 (0.34) | HPGDALDH1A1TP53CYP3A4LPAR5 | |
| SCHEMBL10888473 | 0.83 | TSHR (0.59) | TSHRHPGDALDH1A1TP53HIF1A | |
| SCHEMBL344379 | 0.83 | TSHR (0.57) | TSHRHPGDALDH1A1TP53HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025022004-A2 | OPHTHALMIC LENS | CONTAMAC LIMITED (GB) | 2025-01-30 | — | — | WO | claimed |
| WO-2025022004-A2 | OPHTHALMIC LENS | CONTAMAC LIMITED (GB) | 2025-01-30 | — | — | WO | disclosed |
| EP-2049922-B1 | ACRYLOYL MATERIALS FOR MOLDED PLASTICS | JOHNSON & JOHNSON VISION CARE (US) | 2016-07-13 | — | — | EP | disclosed |
| US-8637589-B2 | Silicone prepolymer solutions | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2014-01-28 | — | — | US | disclosed |
| US-8637589-B2 | Silicone prepolymer solutions | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2014-01-28 | — | — | US | disclosed |
| US-8569538-B2 | Acryloyl materials for molded plastics | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-8569538-B2 | Acryloyl materials for molded plastics | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-8399539-B2 | Soluble silicone prepolymers | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2013-03-19 | — | — | US | disclosed |
| US-20120065348-A1 | SOLUBLE SILICONE PREPOLYMERS | TORAY INDUSTRIES, INC. (JP) | 2012-03-15 | — | — | US | disclosed |
| US-8080622-B2 | Soluble silicone prepolymers | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2011-12-20 | — | — | US | disclosed |
| US-8080622-B2 | Soluble silicone prepolymers | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2011-12-20 | — | — | US | disclosed |
| US-8053539-B2 | Prepared by purifying acrylic siloxanyl containing monomers by distillation in the presence of at least one polymerization inhibitor which can be an alkylhydroquinone or a hydroxynaphthalene; without substantial amounts of polymerization product(s) and without discoloration; contact lenses | JOHNSON & JOHNSON VISION CARE INC. (US) | 2011-11-08 | — | — | US | disclosed |
| US-20110077322-A1 | Silicone Prepolymer Solutions | TORAY INDUSTRIES, INC. (JP) | 2011-03-31 | — | — | US | disclosed |
| US-7897654-B2 | Silicone prepolymer solutions | JOHNSON & JOHNSON VISION CARE INC. (US) | 2011-03-01 | — | — | US | disclosed |
| US-20090171026-A1 | SILICONE PREPOLYMER SOLUTIONS | JOHNSON & JOHNSON VISION CARE, INC. | 2009-07-02 | — | — | US | disclosed |
| US-20090005528-A1 | SOLUBLE SILICONE PREPOLYMERS | JOHNSON & JOHNSON VISION CARE, INC. | 2009-01-01 | — | — | US | disclosed |
| US-20080004401-A1 | SILOXANYL MATERIALS FOR MOLDED PLASTICS | JOHNSON & JOHNSON VISION CARE, INC. | 2008-01-03 | — | — | US | disclosed |
| US-20080004383-A1 | ACRYLOYL MATERIALS FOR MOLDED PLASTICS | TORAY INDUSTRIES, INC. (JP) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005528-A1 | SOLUBLE SILICONE PREPOLYMERS | NOS3, NOS2, PCNA | TSHR 4182/4885HPGD 97/4885ALDH1A1 2292/4885 |
| US-20080004383-A1 | ACRYLOYL MATERIALS FOR MOLDED PLASTICS | ACR, HAAO, PORCN | TSHR 4861/4885HPGD 583/4885ALDH1A1 515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.