Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6256299 | 0.86 | CYP2D6 (0.49) | CYP2D6CYP1A2TSHRHIF1ANFKB1 | |
| SCHEMBL4595038 | 0.86 | CYP2D6 (0.49) | CYP2D6CYP1A2TSHRHIF1ANFKB1 | |
| SCHEMBL6232927 | 0.79 | CYP2D6 (0.33) | ALDH1A1GLASMN1; SMN2HTTCYP2D6 | |
| SCHEMBL21995575 | 0.76 | — | — | |
| SCHEMBL31037751 | 0.73 | L3MBTL1 (0.37) | ALDH1A1GLASMN1; SMN2HTTCYP2D6 | |
| SCHEMBL1049767 | 0.73 | — | — | |
| SCHEMBL6752549 | 0.73 | ITGB3 (0.37) | L3MBTL1 | |
| SCHEMBL31564618 | 0.72 | SPHK1 (0.30) | — | |
| SCHEMBL1051333 | 0.72 | PSMB11 (0.35) | HTTPOLB | |
| SCHEMBL3389163 | 0.72 | PSMB11 (0.35) | HTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539731-B9 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-08-20 | — | — | EP | disclosed |
| EP-1539731-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-01-02 | — | — | EP | disclosed |
| US-20050203172-A1 | Novel compounds | ASTRAZENECA AB (SE) | 2005-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203172-A1 | Novel compounds | NOS3, NOS1, NOS2 | ALDH1A1 703/4885GLA 2976/4885SMN1; SMN2 1900/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.