Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28988607 | 0.82 | NPC1 (0.41) | BRD4KDM4EALDH1A1GAAHPGD | |
| SCHEMBL996893 | 0.78 | ESR1 (0.43) | BRD4OPRK1PDE3BPDE3AKDM4E | |
| SCHEMBL998573 | 0.77 | OPRK1 (0.54) | BRD4OPRK1PDE3BPDE3AKDM4E | |
| SCHEMBL998539 | 0.77 | ALDH1A1 (0.47) | BRD4OPRK1PDE3BPDE3AKDM4E | |
| SCHEMBL7615987 | 0.76 | OPRK1 (0.44) | OPRK1PDE3BPDE3AKDM4EALDH1A1 | |
| SCHEMBL996565 | 0.76 | ALDH1A1 (0.49) | OPRK1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7642155 | 0.74 | NSD3 (0.41) | PDE3BPDE3AKDM4ENSD3KMT2A | |
| SCHEMBL7642157 | 0.74 | NSD3 (0.41) | PDE3BPDE3AKDM4ENSD3KMT2A | |
| SCHEMBL998566 | 0.74 | OPRK1 (0.48) | BRD4OPRK1PDE3BPDE3AALDH1A1 | |
| SCHEMBL15135262 | 0.74 | MAPT (0.51) | BRD4KDM4EALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7367993-B2 | Dyeing compositions comprising at least one 1,3-indandione derivative | L'OREAL S.A. (FR) | 2008-05-06 | — | — | US | claimed |
| EP-1502580-B1 | Use in dyeing of aromatic polycyclic vicinal triones with condensed cycles | OREAL (FR) | 2008-01-23 | — | — | EP | claimed |
| EP-1500387-B1 | Use of ninhydrin derivatives for dyeing | OREAL (FR) | 2008-01-09 | — | — | EP | claimed |
| US-7182791-B2 | Composition and method of dyeing keratin fibers comprising at least one heteroalkyl group comprising at least one ninhydrin derivative | L'OREAL S.A. (FR) | 2007-02-27 | — | — | US | claimed |
| US-7179306-B2 | Process for dying keratin fibers comprising at least one aryl or aryloxy substitutent-based ninhydrin derivative | L'OREAL S.A. (FR) | 2007-02-20 | — | — | US | claimed |
| US-7179304-B2 | Process for dyeing keratin fibers with at least one polycyclic aromatic vicinal trione | L'OREAL S.A. (FR) | 2007-02-20 | — | — | US | claimed |
| US-20050283923-A1 | Dyeing compositions comprising A 1,2-indandione derivative | L'OREAL S.A. (FR) | 2005-12-29 | — | — | US | claimed |
| US-20050283922-A1 | Dyeing compositions comprising at least one 1,3-indandione derivative | L'OREAL S.A. (FR) | 2005-12-29 | — | — | US | claimed |
| EP-1609458-A1 | Dye composition comprising derivatives of 1,3-indandione | L'OREAL (FR) | 2005-12-28 | — | — | EP | claimed |
| EP-1609457-A1 | Dye composition comprising derivative of 1,2-indandione | L'OREAL (FR) | 2005-12-28 | — | — | EP | claimed |
| EP-1537851-A1 | Use of ninhydrin derivatives in colouring | L'OREAL (FR) | 2005-06-08 | — | — | EP | claimed |
| EP-1537852-A1 | Use of ninhydrin derivatives in colouring | L'OREAL (FR) | 2005-06-08 | — | — | EP | claimed |
| EP-1535600-A1 | Use of derivatives of ninhydrin carrying an unsaturated system in colouring | L'OREAL (FR) | 2005-06-01 | — | — | EP | claimed |
| EP-1535601-A1 | Use of ninhydrin derivatives in colouring | L'OREAL (FR) | 2005-06-01 | — | — | EP | claimed |
| EP-1530963-A1 | Use of ninhydrin derivatives in colouring | L'OREAL (FR) | 2005-05-18 | — | — | EP | claimed |
| US-20050060818-A1 | Composition and method of dyeing keratin fibers comprising at least one heteroalkyl group comprising at least one ninhydrin derivative | L'OREAL S.A. (FR) | 2005-03-24 | — | — | US | claimed |
| US-20050050652-A1 | Process for dyeing keratin fibers with at least one polycyclic aromatic vicinal trione | L'OREAL S.A. (FR) | 2005-03-10 | — | — | US | claimed |
| US-20050050655-A1 | Process for dyeing keratin fibers comprising at least one aryl or aryloxy substitutent-based ninhydrin derivative | L'OREAL S.A. (FR) | 2005-03-10 | — | — | US | claimed |
| EP-1502580-A1 | Use in dyeing of aromatic polycyclic vicinal triones with condensed cycles | L'OREAL (FR) | 2005-02-02 | — | — | EP | claimed |
| EP-1500387-A1 | Use of ninhydrin derivatives for dyeing | L'OREAL (FR) | 2005-01-26 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050283922-A1 | Dyeing compositions comprising at least one 1,3-indandione derivative | KRT18, DSG1, IK | BRD4 1395/4885OPRK1 3599/4885PDE3B 3315/4885 |
| US-20050050652-A1 | Process for dyeing keratin fibers with at least one polycyclic aromatic vicinal trione | KRT18, HKDC1, JUP | BRD4 3121/4885OPRK1 4127/4885PDE3B 4628/4885 |
| US-20050283923-A1 | Dyeing compositions comprising A 1,2-indandione derivative | KRT18, DSG1, KRTCAP2 | BRD4 1200/4885OPRK1 4349/4885PDE3B 3973/4885 |
| US-20050060818-A1 | Composition and method of dyeing keratin fibers comprising at least one heteroalkyl group comprising at least one ninhydrin derivative | KRT18, C9, S100A6 | BRD4 908/4885OPRK1 2486/4885PDE3B 4826/4885 |
| US-20050050655-A1 | Process for dyeing keratin fibers comprising at least one aryl or aryloxy substitutent-based ninhydrin derivative | KRT18, JUP, NISCH | BRD4 1632/4885OPRK1 3103/4885PDE3B 4143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.