Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL549278 | 0.88 | HPGD (0.46) | LMNAHPGDALDH1A1MAPTTDP1 | |
| SCHEMBL14070022 | 0.84 | LMNA (0.64) | LMNAHPGDALDH1A1MAPTTDP1 | |
| SCHEMBL4451990 | 0.78 | LMNA (0.58) | LMNAHPGDALDH1A1MAPTTDP1 | |
| SCHEMBL8005199 | 0.77 | CYP3A4 (0.44) | LMNAHPGDALDH1A1MAPTTDP1 | |
| SCHEMBL17821971 | 0.76 | LMNA (0.40) | LMNAHPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL17821970 | 0.76 | LMNA (0.40) | LMNAHPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL1128702 | 0.76 | HPGD (0.56) | LMNAHPGDALDH1A1MAPTTDP1 | |
| SCHEMBL31123847 | 0.76 | HPGD (0.56) | LMNAHPGDALDH1A1MAPTTDP1 | |
| SCHEMBL4134378 | 0.75 | LMNA (0.55) | LMNAHPGDALDH1A1MAPTTDP1 | |
| SCHEMBL22133239 | 0.75 | LMNA (0.55) | LMNAHPGDALDH1A1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250025443-A1 | COMPOUNDS AND METHODS FOR TREATING CORONA VIRUSES | Clear Creek Bio, Inc. (US) | 2025-01-23 | — | — | US | disclosed |
| US-20240300962-A1 | Isoquinoline Derivatives, Methods of Synthesis and Uses Thereof | PROSETTA BIOSCIENCES INC (US) | 2024-09-12 | — | — | US | disclosed |
| US-12024521-B2 | Isoquinoline derivatives, methods of synthesis and uses thereof | PROSETTA BIOSCIENCES, INC. (US) | 2024-07-02 | — | — | US | disclosed |
| US-11664093-B2 | Extrapolative prediction of enantioselectivity enabled by computer-driven workflow, new molecular representations and machine learning | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2023-05-30 | — | — | US | disclosed |
| WO-2023064493-A1 | COMPOUNDS AND METHODS FOR TREATING CORONAVIRUSES | Clear Creek Bio, Inc. (US) | 2023-04-20 | — | — | WO | disclosed |
| WO-2023064493-A1 | COMPOUNDS AND METHODS FOR TREATING CORONAVIRUSES | Clear Creek Bio, Inc. (US) | 2023-04-20 | — | — | WO | disclosed |
| EP-4149471-A1 | ISOQUINOLINE DERIVATIVES, METHODS OF SYNTHESIS AND USES THEREOF | Prosetta Biosciences, Inc. (US) | 2023-03-22 | — | — | EP | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| WO-2022006228-A1 | ISOQUINOLINE DERIVATIVES, METHODS OF SYNTHESIS AND USES THEREOF | PROSETTA BIOSCIENCES, INC. (US) | 2022-01-06 | — | — | WO | disclosed |
| US-20210403477-A1 | Isoquinoline Derivatives, Methods of Synthesis and Uses Thereof | PROSETTA BIOSCIENCES, INC. | 2021-12-30 | — | — | US | disclosed |
| US-20010014684-A1 | THIENO-PYRIDINE SULFONAMIDES DERIVATIVES THEREOF AND RELATED COMPOUNDS THAT MODULATE THE ACTIVITY OF ENDOTHELIN | ENCYSIVE PHARMACEUTICALS INC. | 2001-08-16 | — | — | US | disclosed |
| US-6013655-A | HYPOTENSIVE AGENTS; RESPIRATORY SYSTEM DIISORDERS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2000-01-11 | — | — | US | disclosed |
| EP-0898571-A1 | THIENO-PYRIDINE SULFONAMIDES, DERIVATIVES THEREOF AND RELATED COMPOUNDS THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5804585-A | INHIBIT BINDING OF ENDOTHELIN PEPTIDE TO ENDOTHELIN RECEPTORS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1998-09-08 | — | — | US | disclosed |
| WO-1997039000-A1 | THIENO-PYRIDINE SULFONAMIDES, DERIVATIVES THEREOF AND RELATED COMPOUNDS THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1997-10-23 | — | — | WO | disclosed |
| US-5475024-A | Useful in treating liver disease | EISAI CO., LTD. (JP) | 1995-12-12 | — | — | US | disclosed |
| US-5292901-A | Benzodioxole derivatives | EISAI CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| EP-0281098-B1 | BENZODIOXOLE DERIVATIVES, COMPOSITIONS COMPRISING THE SAME, AND THE USE OF THE SAME FOR THE MANUFACTURE OF MEDICAMENTS | Eisai Co., Ltd. (JP) | 1992-11-25 | — | — | EP | disclosed |
| US-5110956-A | Liver disorders | EISAI CO., LTD. (JP) | 1992-05-05 | — | — | US | disclosed |
| EP-0281098-A1 | Benzodioxole derivatives, compositions comprising the same, and the use of the same for the manufacture of medicaments | Eisai Co., Ltd. (JP) | 1988-09-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12024521-B2 | Isoquinoline derivatives, methods of synthesis and uses thereof | POLRMT, MAVS, SYNCRIP | LMNA 772/4885HPGD 989/4885ALDH1A1 3238/4885 |
| US-20210403477-A1 | Isoquinoline Derivatives, Methods of Synthesis and Uses Thereof | POLRMT, MAVS, SYNCRIP | LMNA 772/4885HPGD 989/4885ALDH1A1 3238/4885 |
| US-20240300962-A1 | Isoquinoline Derivatives, Methods of Synthesis and Uses Thereof | POLRMT, MAVS, SYNCRIP | LMNA 772/4885HPGD 989/4885ALDH1A1 3238/4885 |
| US-20010014684-A1 | THIENO-PYRIDINE SULFONAMIDES DERIVATIVES THEREOF AND RELATED COMPOUNDS THAT MODULATE THE ACTIVITY OF ENDOTHELIN | EDNRB, EDNRA, AGTR1 | LMNA 2948/4885HPGD 968/4885ALDH1A1 4060/4885 |
| US-20250025443-A1 | COMPOUNDS AND METHODS FOR TREATING CORONA VIRUSES | ACE, PREP, PEPD | LMNA 627/4885HPGD 2322/4885ALDH1A1 2460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.