Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA1 | P02708 | 1/20 | 0.32 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 5/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596506 | 0.87 | DRD2 (0.34) | CHRNA1CHRNB1CHRNB2SLC6A2CHRNB4 | |
| SCHEMBL4596625 | 0.87 | HTR2C (0.35) | CHRNA1CHRNB1CHRNB2SLC6A2CHRNB4 | |
| SCHEMBL4597256 | 0.87 | DRD2 (0.34) | CHRNA1CHRNB1CHRNB2SLC6A2CHRNB4 | |
| SCHEMBL4596041 | 0.87 | KDM4E (0.32) | KDM1AKDM4EALDH1A1OPRM1OPRL1 | |
| SCHEMBL4597510 | 0.87 | KDM4E (0.32) | KDM1AKDM4EALDH1A1OPRM1OPRL1 | |
| SCHEMBL4596707 | 0.78 | GABRA1 (0.32) | — | |
| SCHEMBL4597792 | 0.77 | CHRM2 (0.34) | SLC6A2SLC6A4SLC6A3BACE1PLAT | |
| SCHEMBL4625414 | 0.77 | CHRM2 (0.34) | SLC6A2SLC6A4SLC6A3BACE1PLAT | |
| SCHEMBL4596366 | 0.77 | CHRM2 (0.37) | SLC6A4SLC6A3HTR6OPRM1OPRL1 | |
| SCHEMBL4596721 | 0.77 | CHRM2 (0.37) | SLC6A4SLC6A3HTR6OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924265-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | Genzyme Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007022371-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |