Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 5/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.36 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.36 |
| ▸ | CHRNG | P07510 | 2/20 | 0.36 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | CHRND | Q07001 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596366 | 0.77 | CHRM2 (0.37) | BACE1DPP4DPP9DPP8SLC6A3 | |
| SCHEMBL4596721 | 0.77 | CHRM2 (0.37) | BACE1DPP4DPP9DPP8SLC6A3 | |
| SCHEMBL4597825 | 0.76 | CHRM2 (0.39) | DPP4DPP9SLC6A4DRD2HTR2A | |
| SCHEMBL4597871 | 0.75 | SLC6A2 (0.40) | DPP4DPP9DPP8SLC6A2SLC6A3 | |
| SCHEMBL4596506 | 0.75 | DRD2 (0.34) | BACE1DPP4DPP9DPP8CHRNA1 | |
| SCHEMBL4597256 | 0.75 | DRD2 (0.34) | BACE1DPP4DPP9DPP8CHRNA1 | |
| SCHEMBL4598352 | 0.75 | SLC6A4 (0.41) | BACE1DPP4DPP9SLC6A2SLC6A3 | |
| SCHEMBL4598045 | 0.74 | SLC6A4 (0.43) | DPP4DPP9DPP8SLC6A2SLC6A3 | |
| SCHEMBL4597579 | 0.73 | DRD2 (0.33) | DPP4DPP9HSD11B1DPP8CHRNA1 | |
| SCHEMBL4597548 | 0.69 | DRD2 (0.36) | DPP4DPP9DPP8SLC6A4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924265-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | Genzyme Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007022371-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |