Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 3/20 | 0.33 |
| ▸ | FADS1 | O60427 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4598352 | 0.84 | SLC6A4 (0.41) | DRD2KCNH2DPP4DPP9HTR6 | |
| SCHEMBL5179386 | 0.80 | GRIN1 (0.38) | CHRM2CHRM3HTR2AHTR2CHTR6 | |
| SCHEMBL4596721 | 0.76 | CHRM2 (0.37) | CHRM2CHRM3CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4596366 | 0.76 | CHRM2 (0.37) | CHRM2CHRM3CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL4597529 | 0.76 | BACE1 (0.38) | CYP2D6CYP2C9CYP2C19HTR2AHTR2C | |
| SCHEMBL4597256 | 0.73 | DRD2 (0.34) | CYP2D6CYP2C9CYP2C19HTR2AHTR2C | |
| SCHEMBL4596506 | 0.73 | DRD2 (0.34) | CYP2D6CYP2C9CYP2C19HTR2AHTR2C | |
| SCHEMBL4597871 | 0.72 | SLC6A2 (0.40) | DRD2KCNH2DPP4DPP9HTR6 | |
| SCHEMBL4597579 | 0.72 | DRD2 (0.33) | CYP2D6CYP2C9CYP2C19HTR2AHTR2C | |
| SCHEMBL4598182 | 0.71 | GRIN1 (0.36) | CHRM2CHRM3CYP2C19TP53CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924265-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | Genzyme Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007022371-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |