Sugi Predict

Sugi Predict / Compounds / SCHEMBL4597600

SCHEMBL4597600

SCHEMBL4597600

COC(=O)c1c(N2CCOCC2)c2c(c3cc(C)ccc13)OC(c1ccccc1)(c1ccc(OC)cc1)C=C2

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 3/20 0.37
▸ KMT2A Q03164 3/20 0.37
▸ SMN1; SMN2 Q16637 3/20 0.37
▸ MAPT P10636 3/20 0.37
▸ NPC1 O15118 2/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ RXFP1 Q9HBX9 1/20 0.37
▸ ALDH1A1 P00352 7/20 0.37
▸ HSD17B10 Q99714 4/20 0.37
▸ KDM4E B2RXH2 3/20 0.37
▸ HPGD P15428 2/20 0.37
▸ GAA P10253 1/20 0.37
▸ TP53 P04637 2/20 0.36
▸ TSHR P16473 1/20 0.36
▸ TDP1 Q9NUW8 1/20 0.36
▸ L3MBTL1 Q9Y468 2/20 0.35
▸ PIK3CA P42336 1/20 0.35
▸ PIK3CB P42338 1/20 0.35
▸ PKM P14618 1/20 0.34
▸ HTT P42858 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4597892 0.94 ALDH1A1 (0.39) MEN1KMT2ASMN1; SMN2MAPTNPC1
SCHEMBL8919915 0.85 MEN1 (0.38) MEN1KMT2AMAPTALDH1A1HSD17B10
SCHEMBL6131993 0.79 ALDH1A1 (0.36) MEN1KMT2ASMN1; SMN2MAPTNPC1
SCHEMBL4598124 0.79 ALDH1A1 (0.49) MEN1KMT2ASMN1; SMN2RXFP1ALDH1A1
SCHEMBL6172997 0.78 PLA2G2A (0.38) MEN1KMT2ANPC1RAB9AALDH1A1
SCHEMBL5551024 0.76 KMT2A (0.42) MEN1KMT2ASMN1; SMN2MAPTNPC1
SCHEMBL5160384 0.76 MAPT (0.40) MEN1KMT2ASMN1; SMN2MAPTNPC1
SCHEMBL29565668 0.76 PLA2G2A (0.37) MEN1KMT2ASMN1; SMN2MAPTALDH1A1
SCHEMBL4597867 0.76 PLA2G2A (0.37) MEN1KMT2ASMN1; SMN2MAPTALDH1A1
SCHEMBL5550214 0.76 KMT2A (0.47) MEN1KMT2ASMN1; SMN2MAPTRXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1877856-A1 PHOTOCHROMIC BLUE LIGHT FILTERING MATERIALS AND OPHTHALMIC DEVICES Bausch & Lomb Incorporated (US) 2008-01-16 — — EP claimed
US-20070159594-A9 Photochromic blue light filtering materials and ophthalmic devices BAUSCH & LOMB INCORPORATED 2007-07-12 — — US claimed
WO-2006119328-A1 PHOTOCHROMIC BLUE LIGHT FILTERING MATERIALS AND OPHTHALMIC DEVICES BAUSCH & LOMB INCORPORATED (US) 2006-11-09 — — WO claimed
US-20050254003-A1 Photochromic blue light filtering materials and ophthalmic devices BAUSCH & LOMB INCORPORATED 2005-11-17 — — US claimed
US-6353102-B1 FOR OPHTHALMIC LENSES OR CONTACT LENSES PPG INDUSTRIES OHIO, INC. 2002-03-05 — — US claimed
US-10758643-B2 Mechanophoric medical product AESCULAP AG (DE) 2020-09-01 — — US disclosed
EP-3331581-B1 MECHANOPHORIC MEDICAL PRODUKT AESCULAP AG (DE) 2020-07-08 — — EP disclosed
US-20190151502-A1 Mechanophoric Medical Product AESCULAP AG (DE) 2019-05-23 — — US disclosed
EP-3331581-A1 MECHANOPHORIC MEDICAL PRODUCT Aesculap AG (DE) 2018-06-13 — — EP disclosed
WO-2017025408-A1 MECHANOPHORIC MEDICAL PRODUCT AESCULAP AG (DE) 2017-02-16 — — WO disclosed
EP-1877856-A1 PHOTOCHROMIC BLUE LIGHT FILTERING MATERIALS AND OPHTHALMIC DEVICES Bausch & Lomb Incorporated (US) 2008-01-16 — — EP disclosed
US-20070159594-A9 Photochromic blue light filtering materials and ophthalmic devices BAUSCH & LOMB INCORPORATED 2007-07-12 — — US disclosed
WO-2006119328-A1 PHOTOCHROMIC BLUE LIGHT FILTERING MATERIALS AND OPHTHALMIC DEVICES BAUSCH & LOMB INCORPORATED (US) 2006-11-09 — — WO disclosed
US-20050254003-A1 Photochromic blue light filtering materials and ophthalmic devices BAUSCH & LOMB INCORPORATED 2005-11-17 — — US disclosed
US-6353102-B1 FOR OPHTHALMIC LENSES OR CONTACT LENSES PPG INDUSTRIES OHIO, INC. 2002-03-05 — — US disclosed