Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 5/20 | 0.77 |
| ▸ | ACHE | P22303 | 2/20 | 0.77 |
| ▸ | ALDH3A1 | P30838 | 6/20 | 0.76 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.76 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.76 |
| ▸ | BCHE | P06276 | 3/20 | 0.74 |
| ▸ | CES2 | O00748 | 1/20 | 0.74 |
| ▸ | CASP3 | P42574 | 1/20 | 0.74 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.72 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.72 |
| ▸ | APAF1 | O14727 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30774308 | 1.00 | CES1 (0.77) | CES1ACHEALDH3A1CHRM1ALDH1A1 | |
| SCHEMBL18288159 | 0.92 | CES1 (0.90) | CES1ACHEALDH3A1CHRM1ALDH1A1 | |
| SCHEMBL29506660 | 0.86 | ALDH1A1 (1.00) | CES1ACHEALDH3A1CHRM1ALDH1A1 | |
| SCHEMBL2087729 | 0.86 | ALDH1A1 (1.00) | CES1ACHEALDH3A1CHRM1ALDH1A1 | |
| SCHEMBL18954797 | 0.86 | ALDH1A1 (0.69) | CES1ACHEALDH3A1CHRM1ALDH1A1 | |
| SCHEMBL13442861 | 0.85 | CASP3 (1.00) | CES1ACHEALDH3A1CHRM1ALDH1A1 | |
| SCHEMBL3027106 | 0.85 | CES1 (1.00) | CES1ACHEALDH3A1CHRM1ALDH1A1 | |
| SCHEMBL18974709 | 0.84 | CASP3 (0.57) | CES1ACHEALDH3A1CHRM1ALDH1A1 | |
| SCHEMBL10960133 | 0.84 | CES1 (0.77) | CES1ACHEALDH3A1CHRM1ALDH1A1 | |
| SCHEMBL22589515 | 0.84 | CHRM1 (0.77) | CES1ACHEALDH3A1CHRM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260078111-A1 | CARBONIC ANHYDRASE ENZYME INHIBITORS AND METHODS OF USE THEREOF | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2026-03-19 | — | — | US | disclosed |
| EP-4630401-A2 | CARBONIC ANHYDRASE ENZYME INHIBITORS AND METHODS OF USE THEREOF | Rutgers, the State University of New Jersey (US) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024124023-A2 | CARBONIC ANHYDRASE ENZYME INHIBITORS AND METHODS OF USE THEREOF | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2024-06-13 | — | — | WO | disclosed |
| US-20220267329-A1 | Dihydro-Spiro[Indoline-3:1'-Isoquinolin]-2-Ones and Their Analogues and Derivatives and Methods of Treating Cancer and Other Diseases | THE UNIV OF BUEA (CM) | 2022-08-25 | — | — | US | disclosed |
| US-20220071956-A1 | COMPOSITION FOR SUPRESSING SECRETION OF EXTRACELLULAR VESICLES | NISSAN CHEMICAL CORPORATION (JP) | 2022-03-10 | — | — | US | disclosed |
| WO-2020183307-A1 | DIHYDRO-SPIRO[INDOLINE-3:1'-ISOQUINOLIN]-2-ONES AND THEIR ANALOGUES AND DERIVATIVES AND METHODS OF TREATING CANCER AND OTHER DISEASES | THE UNIVERSITY OF BUEA (CM) | 2020-09-17 | — | — | WO | disclosed |
| WO-2017099695-A1 | N-[(AMINOSULFONYL)PHENYL]-2-(1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE)-HYDRAZINECARBOTHIOAMIDE DERIVATIVES FOR TREATING CANCER AND IMMUNOLOGICAL DISORDERS | ISTANBUL UNIVERSITESI REKTORLUGU (TR) | 2017-06-15 | — | — | WO | disclosed |
| WO-2012049555-A1 | SPIROCYCLIC COMPOUNDS AS VOLTAGE-GATED SODIUM CHANNEL MODULATORS | LUPIN LIMITED (IN) | 2012-04-19 | — | — | WO | disclosed |
| EP-1877378-A2 | OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2008-01-16 | — | — | EP | disclosed |
| US-20070105820-A1 | Oxindole compounds and their uses as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2007-05-10 | — | — | US | disclosed |
| WO-2006113864-A2 | OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2006-10-26 | — | — | WO | disclosed |
| US-20020028936-A1 | 1,3-disubstituted indolin-2-ones for neoplasia | OSI PHARMACEUTICALS, INC. | 2002-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105820-A1 | Oxindole compounds and their uses as therapeutic agents | OPRL1, OPRK1, TRPV1 | CES1 4183/4885ACHE 270/4885ALDH3A1 1159/4885 |
| US-20020028936-A1 | 1,3-disubstituted indolin-2-ones for neoplasia | TP53, MYC, VHL | CES1 2936/4885ACHE 4845/4885ALDH3A1 561/4885 |
| US-20220071956-A1 | COMPOSITION FOR SUPRESSING SECRETION OF EXTRACELLULAR VESICLES | EXOSC9, EXOSC10, EXOSC5 | CES1 1033/4885ACHE 3219/4885ALDH3A1 4167/4885 |
| US-20220267329-A1 | Dihydro-Spiro[Indoline-3:1'-Isoquinolin]-2-Ones and Their Analogues and Derivatives and Methods of Treating Cancer and Other Diseases | S1PR3, S1PR1, S1PR2 | CES1 2269/4885ACHE 4096/4885ALDH3A1 796/4885 |
| US-20260078111-A1 | CARBONIC ANHYDRASE ENZYME INHIBITORS AND METHODS OF USE THEREOF | CA6, CA9, CA7 | CES1 12/4885ACHE 1545/4885ALDH3A1 58/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.