Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12565677 | 0.90 | TAAR1 (0.49) | GRM4TAAR1HSD17B10ALDH1A1CASP1 | |
| SCHEMBL4824140 | 0.89 | GRM4 (0.39) | GRM4TAAR1PSEN1PSEN2APH1B | |
| SCHEMBL4598374 | 0.85 | GRM4 (0.44) | GRM4TAAR1PSEN1PSEN2APH1B | |
| SCHEMBL4824953 | 0.85 | GRM4 (0.44) | GRM4TAAR1PSEN1PSEN2APH1B | |
| SCHEMBL9517661 | 0.84 | GRM4 (0.43) | GRM4TAAR1PSEN1PSEN2APH1B | |
| SCHEMBL16360896 | 0.82 | F2 (0.43) | GRM4TAAR1PSEN1PSEN2APH1B | |
| SCHEMBL4598385 | 0.81 | TAAR1 (0.40) | GRM4TAAR1HSD17B10ALDH1A1CASP1 | |
| SCHEMBL9517628 | 0.81 | GRM4 (0.41) | GRM4TAAR1PSEN1PSEN2APH1B | |
| SCHEMBL4819619 | 0.80 | L3MBTL1 (0.47) | GRM4TAAR1PSEN1PSEN2APH1B | |
| SCHEMBL14462915 | 0.77 | CTSK (0.65) | CTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910286-A2 | CATHEPSIN K INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-04-16 | — | — | EP | disclosed |
| US-7358373-B2 | Cathepsin K inhibitors | ROCHE PALO ALTO LLC (US) | 2008-04-15 | — | — | US | disclosed |
| US-20070032484-A1 | Cathepsin K inhibitors | ROCHE PALO ALTO LLC | 2007-02-08 | — | — | US | disclosed |
| WO-2007014839-A2 | CATHEPSIN K INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032484-A1 | Cathepsin K inhibitors | CTSK, CTSS, CTSF | GRM4 4622/4885TAAR1 2307/4885PSEN1 1444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.