Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 10/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 3/20 | 0.32 |
| ▸ | BACE1 | P56817 | 2/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 4/20 | 0.32 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL457723 | 0.90 | NTRK1 (0.34) | NTRK1DPP8DPP9JAK2RORC | |
| SCHEMBL459071 | 0.86 | NTRK1 (0.33) | NTRK1RORCBDKRB1IDO1 | |
| SCHEMBL457491 | 0.84 | ITGB3 (0.34) | NTRK1RORC | |
| SCHEMBL460033 | 0.80 | RET (0.33) | NTRK1JAK2RORC | |
| SCHEMBL14722673 | 0.77 | GPR119 (0.39) | — | |
| SCHEMBL463438 | 0.76 | HTR2A (0.35) | — | |
| SCHEMBL459878 | 0.76 | HCAR2 (0.32) | NTRK1JAK2 | |
| SCHEMBL459362 | 0.75 | — | — | |
| SCHEMBL457509 | 0.75 | NTRK1 (0.33) | NTRK1JAK2 | |
| SCHEMBL458010 | 0.74 | ITGB3 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |