Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 10/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 3/20 | 0.32 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL457491 | 0.89 | ITGB3 (0.34) | NTRK1RORC | |
| SCHEMBL458010 | 0.81 | ITGB3 (0.34) | SCN9A | |
| SCHEMBL457628 | 0.80 | GPR119 (0.34) | GPR119SCN9A | |
| SCHEMBL459944 | 0.80 | NTRK1 (0.34) | NTRK1JAK2RORC | |
| SCHEMBL457723 | 0.80 | NTRK1 (0.34) | NTRK1JAK2RORC | |
| SCHEMBL463438 | 0.78 | HTR2A (0.35) | — | |
| SCHEMBL459071 | 0.77 | NTRK1 (0.33) | NTRK1RORC | |
| SCHEMBL460034 | 0.76 | CHRM2 (0.38) | RETNTRK1AAK1USP30 | |
| SCHEMBL459362 | 0.74 | — | — | |
| SCHEMBL14722673 | 0.72 | GPR119 (0.39) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |