Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 3/20 | 0.39 |
| ▸ | CTSS | P25774 | 3/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | CTSB | P07858 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4600484 | 0.90 | CTSK (0.40) | CA1CA2ACHELMNASMN1; SMN2 | |
| SCHEMBL4598809 | 0.90 | CTSK (0.40) | CA1CA2ACHELMNASMN1; SMN2 | |
| SCHEMBL22982284 | 0.82 | MEN1 (0.47) | LMNASMN1; SMN2CTSKCTSSCTSL | |
| SCHEMBL5172763 | 0.82 | MEN1 (0.47) | LMNASMN1; SMN2CTSKCTSSCTSL | |
| SCHEMBL4601407 | 0.81 | GPR119 (0.38) | CTSKCTSSSYK | |
| SCHEMBL270533 | 0.78 | CTSL (0.50) | CTSKCTSSCTSLCTSBMEN1 | |
| SCHEMBL23911895 | 0.77 | CTSS (0.51) | LMNASMN1; SMN2CTSKCTSSCTSL | |
| SCHEMBL4598534 | 0.75 | MC4R (0.40) | LMNAMEN1KMT2A | |
| SCHEMBL6468352 | 0.73 | LMNA (0.50) | KCNA5LMNASMN1; SMN2MAPTCTSK | |
| SCHEMBL4597242 | 0.72 | JAK3 (0.42) | LMNACTSKCTSSSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912946-A1 | PYRIDINE DERIVATIVES AS DIPEPTEDYL PEPTIDASE INHIBITORS | Eli Lilly and Company (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007015767-A1 | PYRIDINE DERIVATIVES AS DIPEPTEDYL PEPTIDASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-02-08 | — | — | WO | disclosed |