Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.42 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | RGS12 | O14924 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | LDHB | P07195 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 6/20 | 0.35 |
| ▸ | THRB | P10828 | 6/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL460120 | 0.72 | HSP90AA1 (0.45) | KDM4CNOX4EGFRALDH1A1MAPT | |
| SCHEMBL9204465 | 0.68 | F2R (0.52) | ALDH1A1MAPT | |
| SCHEMBL9198091 | 0.67 | HTT (0.66) | MAPTTDP1 | |
| SCHEMBL9200578 | 0.65 | HPGD (0.49) | MAPTTDP1 | |
| SCHEMBL9201424 | 0.65 | LMNA (0.49) | ALDH1A1MAPTMCL1 | |
| SCHEMBL462566 | 0.65 | EGFR (0.47) | KDM4CNOX4EGFRRGS12ALDH1A1 | |
| SCHEMBL9196782 | 0.64 | MAPT (0.38) | KDM4CALDH1A1MAPTTDP1MCL1 | |
| SCHEMBL9203707 | 0.64 | DHODH (0.56) | ALDH1A1TDP1 | |
| SCHEMBL11242577 | 0.64 | FFAR1 (0.50) | KDM4CALDH1A1MAPTPPARASTING1 | |
| SCHEMBL9199236 | 0.64 | MAPT (0.39) | ALDH1A1MAPTTDP1THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |
| WO-2010033906-A2 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-03-25 | — | — | WO | disclosed |