Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4600425 | 0.82 | MAPT (0.46) | KMT2ASMN1; SMN2MAPTMEN1ALDH1A1 | |
| SCHEMBL4601601 | 0.81 | EGFR (0.47) | KMT2ASMN1; SMN2KDM4EMAPTALDH1A1 | |
| SCHEMBL4600130 | 0.80 | EGFR (0.47) | KMT2ASMN1; SMN2KDM4EMEN1ALDH1A1 | |
| SCHEMBL1340747 | 0.77 | RAB9A (0.83) | RAB9ANPC1RECQLKMT2ASMN1; SMN2 | |
| SCHEMBL4602183 | 0.77 | EGFR (0.47) | NPC1KMT2AMAPTMEN1MAPK1 | |
| SCHEMBL27850556 | 0.77 | TDP1 (0.49) | RAB9ANPC1KMT2ASMN1; SMN2POLB | |
| SCHEMBL4601033 | 0.76 | EGFR (0.44) | KDM4EEGFR | |
| SCHEMBL4600744 | 0.75 | GPR35 (0.47) | RAB9ANPC1RECQLKMT2APOLB | |
| SCHEMBL4600628 | 0.74 | EGFR (0.47) | KMT2AKDM4EMAPTMEN1ALDH1A1 | |
| SCHEMBL28478554 | 0.74 | HSPB1 (0.43) | RAB9ANPC1RECQLKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912645-A2 | THERAPEUTIC AGENT FOR DIABETES | Takeda Pharmaceutical Company Limited (JP) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007018314-A2 | THERAPEUTIC AGENT FOR DIABETES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-15 | — | — | WO | disclosed |