Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | DRD1 | P21728 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | DRD5 | P21918 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4601601 | 0.81 | EGFR (0.47) | EGFRRXFP1HTTTHRBKDM4E | |
| SCHEMBL4602183 | 0.79 | EGFR (0.47) | EGFRTHRBKMT2A | |
| SCHEMBL4600130 | 0.77 | EGFR (0.47) | EGFRRXFP1HTTTHRBKDM4E | |
| SCHEMBL4601033 | 0.76 | EGFR (0.44) | EGFRTHRBKDM4ETHRAHTR2A | |
| SCHEMBL4602169 | 0.76 | EGFR (0.41) | EGFRRXFP1HTTKDM4EKMT2A | |
| SCHEMBL27360839 | 0.75 | THRB (0.42) | THRBDRD2DRD1DRD4DRD5 | |
| SCHEMBL4601218 | 0.74 | MRGPRX4 (0.46) | EGFRRXFP1HTTKDM4EKMT2A | |
| SCHEMBL4600628 | 0.74 | EGFR (0.47) | EGFRTHRBKDM4ETHRAKMT2A | |
| SCHEMBL4601685 | 0.74 | RXFP1 (0.48) | EGFRRXFP1HTTKDM4EKMT2A | |
| SCHEMBL4600843 | 0.74 | RAB9A (0.50) | EGFRHTTKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912645-A2 | THERAPEUTIC AGENT FOR DIABETES | Takeda Pharmaceutical Company Limited (JP) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007018314-A2 | THERAPEUTIC AGENT FOR DIABETES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-15 | — | — | WO | disclosed |