Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4602438 | 0.78 | ALDH1A1 (0.53) | ALDH1A1KMT2AKDM4EMEN1PIM1 | |
| SCHEMBL8329240 | 0.75 | ALDH1A1 (0.56) | ALDH1A1KMT2AKDM4EMEN1TP53 | |
| SCHEMBL2001891 | 0.73 | ALDH1A1 (0.57) | ALDH1A1KMT2AKDM4EMEN1SMN1; SMN2 | |
| SCHEMBL21489525 | 0.71 | GLO1 (0.59) | MMP2ALDH1A1KDM4EKEAP1TP53 | |
| SCHEMBL15882980 | 0.70 | ALDH1A1 (0.54) | ALDH1A1KMT2AKDM4EMEN1PIM1 | |
| SCHEMBL60874 | 0.69 | ALDH1A1 (0.61) | MCL1ALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL2040317 | 0.68 | MCL1 (0.64) | MCL1MMP2ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL2329568 | 0.68 | ALDH1A1 (0.59) | ALDH1A1KMT2AKDM4EMEN1PIM1 | |
| SCHEMBL4533547 | 0.67 | KDM1A (0.60) | MCL1ALDH1A1KMT2AKEAP1SMN1; SMN2 | |
| SCHEMBL31645593 | 0.67 | KDM1A (0.60) | MCL1ALDH1A1KMT2AKEAP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968944-A1 | ALKYLSULPHONAMIDE QUINOLINES | AstraZeneca AB (SE) | 2008-09-17 | — | — | EP | claimed |
| WO-2007069977-A1 | ALKYLSULPHONAMIDE QUINOLINES | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | claimed |