SCHEMBL2276115

SCHEMBL2276115

O=C(O)c1ccc(CCc2ccccc2)cc1NC(=O)C1CC1

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.49
KMT2A Q03164 4/20 0.49
GAA P10253 3/20 0.49
KDM4E B2RXH2 2/20 0.49
DHODH Q02127 1/20 0.45
ALDH1A1 P00352 4/20 0.45
CYP2C19 P33261 1/20 0.45
ACLY P53396 1/20 0.44
RECQL P46063 1/20 0.44
BLM P54132 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
PKM P14618 1/20 0.44
LMNA P02545 2/20 0.43
HCAR2 Q8TDS4 2/20 0.43
MAPT P10636 1/20 0.42
GFER P55789 1/20 0.42
USP2 O75604 1/20 0.41
HPGD P15428 1/20 0.41
DRD4 P21917 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2274782 0.94 ALDH1A1 (0.54) KDM4EALDH1A1CYP2C19RECQLLMNA
SCHEMBL4604120 0.80 ACLY (0.58) KDM4EALDH1A1ACLY
SCHEMBL2275929 0.79 KMT2A (0.62) MEN1KMT2ADHODHACLYTDP1
SCHEMBL5146858 0.79 KDM4C (0.58) MEN1KMT2AKDM4EALDH1A1ACLY
SCHEMBL2275804 0.79 HCAR2 (0.63) HCAR2MAPT
SCHEMBL13738276 0.78 HDAC1 (0.63) ALDH1A1CYP2C19HPGD
SCHEMBL16404476 0.78 ALDH1A1 (0.60) MEN1KMT2AGAAKDM4EALDH1A1
SCHEMBL28170369 0.78 ALDH1A1 (0.60) MEN1KMT2AGAAKDM4EALDH1A1
SCHEMBL2275852 0.77 MEN1 (0.55) MEN1KMT2AALDH1A1CYP2C19RECQL
SCHEMBL4213492 0.77 TAAR1 (0.50) MEN1KMT2AALDH1A1CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 MEN1 3105/4885KMT2A 1669/4885GAA 2590/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.