SCHEMBL2270696

SCHEMBL2270696

O=C(O)c1ccc(Oc2ccccc2)cc1NC(=O)C1CC1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.60
PKM P14618 1/20 0.60
ABL1 P00519 1/20 0.57
MTNR1A P48039 1/20 0.54
MTNR1B P49286 1/20 0.54
KDM4E B2RXH2 3/20 0.52
CYP2C9 P11712 1/20 0.50
CYP2C19 P33261 1/20 0.50
HSD17B10 Q99714 1/20 0.48
ALDH1A1 P00352 1/20 0.48
SMN1; SMN2 Q16637 2/20 0.47
RECQL P46063 1/20 0.47
MAPT P10636 2/20 0.46
HTT P42858 1/20 0.46
RXFP1 Q9HBX9 1/20 0.46
POLB P06746 1/20 0.46
USP2 O75604 1/20 0.46
LTA4H P09960 1/20 0.46
JAK2 O60674 1/20 0.46
RAB9A P51151 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2272904 0.94 KDM4E (0.57) GAAPKMABL1MTNR1AMTNR1B
SCHEMBL4604120 0.80 ACLY (0.58) KDM4EALDH1A1HTT
SCHEMBL4222097 0.80 CYP2C9 (0.57) MTNR1AMTNR1BCYP2C9CYP2C19SMN1; SMN2
SCHEMBL2271588 0.79 SERPINE1 (0.64) PKMMAPTPOLBRAB9A
SCHEMBL28212694 0.78 MTNR1A (0.72) GAAPKMABL1MTNR1AMTNR1B
SCHEMBL11672443 0.78 HDAC1 (0.63) GAAPKMABL1SMN1; SMN2
SCHEMBL16404476 0.78 ALDH1A1 (0.60) GAAPKMKDM4EHSD17B10ALDH1A1
SCHEMBL28170369 0.78 ALDH1A1 (0.60) GAAPKMKDM4EHSD17B10ALDH1A1
SCHEMBL2269563 0.77 STK39 (0.57) CYP2C9CYP2C19ALDH1A1HTT
SCHEMBL4214711 0.77 EPHX1 (0.52) GAAPKMKDM4ECYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 GAA 2590/4885PKM 2367/4885ABL1 2130/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.