Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4604966 | 0.84 | GRM5 (0.38) | ADORA3NPC1RAB9AKDM4EHRH3 | |
| SCHEMBL4604558 | 0.84 | CHRNA7 (0.38) | ADORA3KDM4ESMN1; SMN2 | |
| SCHEMBL4606264 | 0.82 | ADORA3 (0.45) | ADORA3ADORA2AADORA2BADORA1P2RY1 | |
| SCHEMBL4606677 | 0.82 | ALDH1A1 (0.33) | NPC1RAB9AKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL29600941 | 0.74 | ADORA3 (0.53) | ADORA3ADORA2AADORA2BADORA1P2RY1 | |
| SCHEMBL6364194 | 0.73 | — | — | |
| SCHEMBL4604129 | 0.72 | TRPM8 (0.39) | ADORA3ADORA2AADORA1NPC1RAB9A | |
| SCHEMBL6581398 | 0.70 | TDP1 (0.49) | ADORA3ADORA2AADORA2BADORA1TP53 | |
| SCHEMBL6265267 | 0.66 | KCNH2 (0.55) | — | |
| SCHEMBL6934276 | 0.66 | GRM5 (0.36) | RAB9ACHRM3HSD17B10MAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1574505-B1 | 1,2,4-THIADIAZOLE COMPOUNDS AND USE THEREOF | SUMITOMO CHEMICAL CO (JP) | 2008-07-16 | — | — | EP | disclosed |
| US-7361675-B2 | 1,2,4-thiadiazole compounds and use thereof | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 2008-04-22 | — | — | US | disclosed |
| US-20060167266-A1 | 1,2,4- thiadiazole compounds and use thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2006-07-27 | — | — | US | disclosed |
| EP-1574505-A1 | 1,2,4-THIADIAZOLE COMPOUNDS AND USE THEREOF | Sumitomo Chemical Company, Limited (JP) | 2005-09-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167266-A1 | 1,2,4- thiadiazole compounds and use thereof | CBR3, CBR1, NOX3 | ADORA3 497/4885ADORA2A 2646/4885ADORA2B 1609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.