Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 15/20 | 0.67 |
| ▸ | CYP11B1 | P15538 | 12/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL460502 | 0.85 | CYP11B2 (0.56) | CYP11B2CYP11B1ERN1PRKCZ | |
| SCHEMBL10175445 | 0.81 | CYP11B2 (1.00) | CYP11B2CYP11B1ERN1PRKCZCNR1 | |
| SCHEMBL461417 | 0.80 | PDE10A (0.46) | CYP11B2CYP11B1CYP1A2 | |
| SCHEMBL17896743 | 0.76 | CYP11B2 (0.60) | CYP11B2CYP11B1ERN1CYP3A4 | |
| SCHEMBL17896648 | 0.75 | CYP11B2 (0.59) | CYP11B2CYP11B1ERN1CYP1A2CYP3A4 | |
| SCHEMBL463000 | 0.73 | CYP11B2 (0.41) | CYP11B2CYP11B1TLR7 | |
| SCHEMBL434081 | 0.73 | CYP11B2 (0.53) | CYP11B2CYP11B1PRKCZCNR1CNR2 | |
| SCHEMBL17883780 | 0.72 | CYP11B2 (0.68) | CYP11B2CYP11B1ERN1PRKCZCNR1 | |
| SCHEMBL17896761 | 0.71 | CYP11B2 (0.56) | CYP11B2CYP11B1ERN1CYP1A2CYP3A4 | |
| SCHEMBL10175444 | 0.70 | CYP11B2 (0.50) | CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595482-A1 | ALDOSTERONE SYNTHASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-05-29 | — | — | EP | claimed |
| WO-2012012478-A1 | ALDOSTERONE SYNTHASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-26 | — | — | WO | claimed |