Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 9/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 9/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 8/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.37 |
| ▸ | LANCL2 | Q9NS86 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4608590 | 0.85 | RAB9A (0.46) | ADRB3ADRB2ADRB1 | |
| SCHEMBL2996791 | 0.81 | ADRB2 (0.58) | PTK2ADRB3ADRB2ADRB1DNM1 | |
| SCHEMBL4607629 | 0.79 | KDM4E (0.52) | — | |
| SCHEMBL4608607 | 0.79 | ALDH1A1 (0.44) | ADRB3ADRB2ADRB1 | |
| SCHEMBL4606968 | 0.78 | ADRB3 (0.42) | ADRB3ADRB2ADRB1DNM1 | |
| SCHEMBL4607733 | 0.78 | POLB (0.40) | ADRB3ADRB2ADRB1DNM1 | |
| SCHEMBL4605749 | 0.78 | TLR9 (0.49) | ADRB3ADRB2ADRB1 | |
| SCHEMBL4608603 | 0.76 | ADRB3 (0.49) | ADRB3ADRB2ADRB1 | |
| SCHEMBL4605132 | 0.75 | ADRB3 (0.46) | ADRB3ADRB2ADRB1DNM1 | |
| SCHEMBL4608251 | 0.75 | MITF (0.43) | ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945612-A2 | HETEROCYCLIC COMPOUNDS AS PSTAT3/IL-6 INHIBITORS | Orchid Research Laboratories Limited (IN) | 2008-07-23 | — | — | EP | claimed |
| WO-2007042912-A2 | HETEROCYCLIC COMPOUNDS AS PSTAT3/IL-6 INHIBITORS | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2007-04-19 | — | — | WO | claimed |
| EP-1945612-A2 | HETEROCYCLIC COMPOUNDS AS PSTAT3/IL-6 INHIBITORS | Orchid Research Laboratories Limited (IN) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007042912-A2 | HETEROCYCLIC COMPOUNDS AS PSTAT3/IL-6 INHIBITORS | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2007-04-19 | — | — | WO | disclosed |