Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 7/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 7/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4608607 | 0.88 | ALDH1A1 (0.44) | HSD17B10ADRB3ADRB2ADRB1ALDH1A1 | |
| SCHEMBL4607629 | 0.80 | KDM4E (0.52) | HPGDKMT2AHSD17B10ALDH1A1LMNA | |
| SCHEMBL2987310 | 0.80 | ADRB3 (0.59) | ADRB3ADRB2ADRB1ALDH1A1LMNA | |
| SCHEMBL4606968 | 0.79 | ADRB3 (0.42) | KMT2AHSD17B10ADRB3ADRB2ADRB1 | |
| SCHEMBL4605749 | 0.79 | TLR9 (0.49) | POLBADRB3ADRB2ADRB1ALDH1A1 | |
| SCHEMBL4608590 | 0.78 | RAB9A (0.46) | KMT2AADRB3ADRB2ADRB1ALDH1A1 | |
| SCHEMBL4607479 | 0.78 | PTK2 (0.45) | ADRB3ADRB2ADRB1DNM1 | |
| SCHEMBL4605132 | 0.77 | ADRB3 (0.46) | KMT2AADRB3ADRB2ADRB1MAPT | |
| SCHEMBL4608251 | 0.76 | MITF (0.43) | POLBKMT2AADRB3ALDH1A1RAB9A | |
| SCHEMBL4607185 | 0.76 | ADRB3 (0.46) | POLBHPGDHSD17B10ADRB3ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945612-A2 | HETEROCYCLIC COMPOUNDS AS PSTAT3/IL-6 INHIBITORS | Orchid Research Laboratories Limited (IN) | 2008-07-23 | — | — | EP | claimed |
| WO-2007042912-A2 | HETEROCYCLIC COMPOUNDS AS PSTAT3/IL-6 INHIBITORS | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2007-04-19 | — | — | WO | claimed |