Bromide

Bromide

SCHEMBL4608307

Br.CCCCCCOC(=O)CCN1CCCC1

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 known ✓ P08172 1/20 0.50
ADRA2C known ✓ P18825 1/20 0.50
ACHE known ✓ P22303 1/20 0.50
SLC6A2 known ✓ P23975 1/20 0.50
ADRA1A known ✓ P35348 1/20 0.50
SLC6A3 known ✓ Q01959 1/20 0.50
THRB P10828 6/20 0.58
THRA P10827 4/20 0.58
NAAA Q02083 1/20 0.51
DGKA P23743 1/20 0.51
LTA4H P09960 1/20 0.51
ALDH1A1 P00352 3/20 0.50
LMNA P02545 2/20 0.50
CYP1A2 P05177 1/20 0.50
CHRM4 P08173 1/20 0.50
CHRM5 P08912 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2C9 P11712 1/20 0.50
DRD4 P21917 1/20 0.50
HRH2 P25021 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4979398 0.92 NAAA (0.56) THRBTHRANAAADGKALMNA
SCHEMBL11711713 0.92 NAAA (0.56) THRBTHRANAAADGKALMNA
SCHEMBL12014425 0.92 ALDH1A1 (0.57) THRBTHRANAAADGKALTA4H
SCHEMBL12014422 0.90 ALDH1A1 (0.59) THRBTHRADGKALTA4HALDH1A1
SCHEMBL499698 0.88 THRB (0.60) THRBTHRANAAADGKALMNA
SCHEMBL13601500 0.88 THRB (0.60) THRBTHRANAAADGKALMNA
SCHEMBL673095 0.85 DGKA (0.50) THRBTHRANAAADGKAALDH1A1
SCHEMBL11598618 0.85 DGKA (0.50) THRBTHRANAAADGKAALDH1A1
SCHEMBL12120211 0.85 THRB (0.62) THRBTHRANAAADGKAALDH1A1
SCHEMBL12120214 0.85 THRB (0.62) THRBTHRANAAADGKAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1948596-A2 SOFT ANTICHOLINERGIC ESTERS Bodor, Nicholas S. (US) 2008-07-30 EP disclosed
WO-2007058971-A2 SOFT ANTICHOLINERGIC ESTERS BODOR NICHOLAS S (US) 2007-05-24 WO disclosed