Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.46 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.45 |
| ▸ | KDM6B | O15054 | 1/20 | 0.45 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7910018 | 0.81 | L3MBTL1 (0.49) | ALDH1A1SMN1; SMN2KDM4ELMNAKMT2A | |
| SCHEMBL11522354 | 0.81 | TSHR (0.49) | ALDH1A1KDM4ELMNAKMT2ATSHR | |
| SCHEMBL1554426 | 0.81 | TSHR (0.63) | ALDH1A1KDM4EKMT2ATSHRL3MBTL1 | |
| SCHEMBL2327515 | 0.79 | EPHX2 (0.61) | ALDH1A1SMN1; SMN2KDM4ELMNAKMT2A | |
| SCHEMBL8539689 | 0.79 | CYP1A2 (0.53) | ALDH1A1KDM4ELMNAKMT2ATSHR | |
| SCHEMBL8539685 | 0.79 | CYP1A2 (0.53) | ALDH1A1KDM4ELMNAKMT2ATSHR | |
| SCHEMBL11138425 | 0.79 | TSHR (0.55) | ALDH1A1KDM4EKMT2ATSHRL3MBTL1 | |
| SCHEMBL5110430 | 0.79 | TSHR (0.59) | ALDH1A1SMN1; SMN2KDM4ELMNAKMT2A | |
| SCHEMBL3260677 | 0.79 | RAB9A (0.74) | ALDH1A1SMN1; SMN2LMNAKMT2AL3MBTL1 | |
| SCHEMBL3393320 | 0.78 | RAB9A (0.58) | ALDH1A1SMN1; SMN2KDM4ELMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0961825-B1 | MUTANT PENICILLIN G ACYLASES | BRISTOL MYERS SQUIBB CO (US) | 2008-07-30 | — | — | EP | disclosed |
| EP-0961825-A4 | MUTANT PENICILLIN G ACYLASES | BRISTOL MYERS SQUIBB CO (US) | 2002-11-20 | — | — | EP | disclosed |
| US-6403356-B1 | GENETIC ENGINEERED POLYPEPTIDE | BRISTOL-MYERS SQUIBB CO. | 2002-06-11 | — | — | US | disclosed |
| EP-0961825-A1 | MUTANT PENICILLIN G ACYLASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-12-08 | — | — | EP | disclosed |
| WO-1998020120-A1 | MUTANT PENICILLIN G ACYLASES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-05-14 | — | — | WO | disclosed |