Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | WDR5 | P61964 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CCR4 | P51679 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13743275 | 0.92 | KMT2A (0.40) | MAPTALDH1A1KMT2AMAPK1NPSR1 | |
| SCHEMBL4609021 | 0.80 | MAP4K4 (0.41) | CHRM1HRH1KCNH2CCR4DYRK1A | |
| SCHEMBL322079 | 0.79 | KCNQ3 (0.50) | MAPTALDH1A1KMT2AMAPK1NPSR1 | |
| SCHEMBL13743505 | 0.74 | KMT2A (0.39) | MAPTALDH1A1KMT2AKCNH2MAPK1 | |
| SCHEMBL4608577 | 0.73 | ALDH1A1 (0.36) | MAPTALDH1A1KMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL27238154 | 0.73 | JAK3 (0.44) | MAPTALDH1A1KMT2AWDR5CHRM1 | |
| SCHEMBL29133293 | 0.73 | JAK3 (0.44) | MAPTALDH1A1KMT2AWDR5CHRM1 | |
| SCHEMBL13743575 | 0.70 | CKS1B (0.40) | MAPTALDH1A1KDM4EKCNQ3KCNQ2 | |
| SCHEMBL10036177 | 0.69 | WDR5 (0.54) | MAPTALDH1A1KMT2AWDR5MAPK1 | |
| SCHEMBL27238331 | 0.69 | WDR5 (0.43) | MAPTALDH1A1WDR5MAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080261918-A1 | Silicon Compounds and Their Use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-10-23 | — | — | US | disclosed |
| EP-1824863-B1 | SILICON COMPOUNDS AND THEIR USE | TAKEDA CAMBRIDGE LTD (GB) | 2008-10-08 | — | — | EP | disclosed |
| EP-1824863-A1 | SILICON COMPOUNDS AND THEIR USE | Takeda Cambridge Limited (GB) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006064277-A1 | SILICON COMPOUNDS AND THEIR USE | TAKEDA CAMBRIDGE LIMITED (GB) | 2006-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261918-A1 | Silicon Compounds and Their Use | SOST, SIK2, SCLY | MAPT 1574/4885ALDH1A1 2254/4885KMT2A 833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.