Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.47 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | CCR8 | P51685 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185654 | 0.92 | CCR1 (0.50) | SLC40A1CCR1CCR5CCR8HTR1A | |
| SCHEMBL8032037 | 0.82 | CCR1 (0.69) | SLC40A1CCR1CCR5CCR8HTR1A | |
| Hydrochloric Acid SCHEMBL5931340 | 0.82 | RELA (0.41) | SLC40A1CCR1CCR5CCR8PDGFRB | |
| SCHEMBL15195529 | 0.81 | G6PD (0.44) | SLC40A1HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL13621091 | 0.81 | SLC40A1 (0.42) | SLC40A1CCR1CCR5CCR8HTR1A | |
| SCHEMBL8140602 | 0.78 | SLC40A1 (0.43) | SLC40A1CCR1CCR5CCR8HTR1A | |
| SCHEMBL30492645 | 0.78 | CCR1 (0.62) | SLC40A1CCR1CCR5CCR8PDGFRB | |
| SCHEMBL10505657 | 0.78 | CCR1 (0.62) | SLC40A1CCR1CCR5CCR8PDGFRB | |
| SCHEMBL14871760 | 0.77 | HTR1A (0.53) | SLC40A1HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL9605472 | 0.77 | CCR1 (0.45) | SLC40A1CCR1CCR5CCR8HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546168-A4 | PHOTOACTIVATED ANTI-VIRAL AND ANTI-CANCER AGENT | PURDUE RESEARCH FOUNDATION (US) | 2008-03-12 | — | — | EP | disclosed |
| US-20060111335-A1 | Photoactivated anti-viral and anti-cancer agent | PURDUE RESEARCH FOUNDATION | 2006-05-25 | — | — | US | disclosed |
| EP-1546168-A2 | PHOTOACTIVATED ANTI-VIRAL AND ANTI-CANCER AGENT | PURDUE RESEARCH FOUNDATION (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004012667-A2 | PHOTOACTIVATED ANTI-VIRAL AND ANTI-CANCER AGENT | PURDUE RESEARCH FOUNDATION (US) | 2004-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060111335-A1 | Photoactivated anti-viral and anti-cancer agent | TP53, POLI, POLK | SLC40A1 2479/4885CCR1 4643/4885CCR5 4137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.