Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 1/20 | 0.59 |
| ▸ | PTGES | O14684 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.52 |
| ▸ | RHOA | P61586 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4613190 | 1.00 | MIF (0.59) | MIFPTGESALDH1A1MAPTLMNA | |
| SCHEMBL6980510 | 0.88 | PTGES (0.55) | MIFPTGESALDH1A1MAPTLMNA | |
| SCHEMBL6980511 | 0.88 | PTGES (0.55) | MIFPTGESALDH1A1MAPTLMNA | |
| SCHEMBL6980515 | 0.88 | PTGES (0.55) | MIFPTGESALDH1A1MAPTLMNA | |
| SCHEMBL30633008 | 0.86 | ALDH1A1 (0.51) | MIFPTGESALDH1A1MAPTLMNA | |
| SCHEMBL22398056 | 0.86 | ALDH1A1 (0.51) | MIFPTGESALDH1A1MAPTLMNA | |
| SCHEMBL989659 | 0.83 | MAPT (0.64) | PTGESALDH1A1MAPTRHOAHIF1A | |
| SCHEMBL3602553 | 0.83 | MAPT (0.64) | PTGESALDH1A1MAPTRHOAHIF1A | |
| SCHEMBL1174503 | 0.83 | MAPT (0.64) | PTGESALDH1A1MAPTRHOAHIF1A | |
| SCHEMBL16619312 | 0.81 | PTGES (0.52) | MIFPTGESALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230357221-A1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | UNIV MONTREAL (CA) | 2023-11-09 | — | — | US | disclosed |
| US-11760754-B2 | Heterocyclic mitochondrial activity inhibitors and uses thereof | Université de Montréal (CA) | 2023-09-19 | — | — | US | disclosed |
| US-20210387980-A1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | Université de Montréal (CA) | 2021-12-16 | — | — | US | disclosed |
| EP-3704111-A1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | Université de Montréal (CA) | 2020-09-09 | — | — | EP | disclosed |
| EP-1237872-B1 | COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECH INC (US) | 2008-02-27 | — | — | EP | disclosed |
| EP-1237872-A4 | COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECH INC (US) | 2005-06-15 | — | — | EP | disclosed |
| US-20050042274-A1 | Compounds and compositions for delivering active agents | MHR INSTITUTIONAL PARTNERS IIA LP | 2005-02-24 | — | — | US | disclosed |
| US-6693208-B2 | AMINO ACIDS WHICH DELIVER ACTIVE AGENTS TO SELECTED BIOLOGICAL SYSTEMS IN INCREASED OR IMPROVED BIOAVAILABILITY | EMISPHERE TECHNOLOGIES, INC. | 2004-02-17 | — | — | US | disclosed |
| US-20030216589-A1 | Compounds and compositions for delivering active agents | NOVO NORDISK NORTH AMERICA OPERATIONS A/S (DK) | 2003-11-20 | — | — | US | disclosed |
| EP-1237872-A1 | COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | Emisphere Technologies, Inc. (US) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001044199-A1 | COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECHNOLOGIES, INC. (US) | 2001-06-21 | — | — | WO | disclosed |
| US-4333940-A | Ring-fluorinated 4-(monosubstituted-amino) phenyl compounds in inhibiting atherosclerotic lesion development | AMERICAN CYANAMID COMPANY (US) | 1982-06-08 | — | — | US | disclosed |
| US-4243609-A | ANTILIPEMIC AGENTS, ANTIATHEROSCLEROTIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1981-01-06 | — | — | US | disclosed |
| EP-0003663-A2 | Amino-substituted phenyl and heteroaryl compounds, process for their preparation and pharmaceutical compositions containing them | AMERICAN CYANAMID COMPANY (US) | 1979-08-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216589-A1 | Compounds and compositions for delivering active agents | IDUA, ALG1, APOB | MIF 2277/4885PTGES 3816/4885ALDH1A1 3939/4885 |
| US-20230357221-A1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | IDH2, TFAM, IDH1 | MIF 2286/4885PTGES 4002/4885ALDH1A1 2036/4885 |
| US-20050042274-A1 | Compounds and compositions for delivering active agents | SERPINB1, ELANE, MMP8 | MIF 636/4885PTGES 1660/4885ALDH1A1 2208/4885 |
| US-20210387980-A1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | IDH2, TFAM, NUTF2 | MIF 2317/4885PTGES 4141/4885ALDH1A1 2100/4885 |
| US-11760754-B2 | Heterocyclic mitochondrial activity inhibitors and uses thereof | IDH2, TFAM, NUTF2 | MIF 2317/4885PTGES 4141/4885ALDH1A1 2100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.