Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.37 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3451288 | 0.84 | KMT2A (0.46) | KMT2AMEN1CYP1A2CYP2D6HIF1A | |
| SCHEMBL24359355 | 0.84 | KMT2A (0.46) | KMT2AMEN1CYP1A2CYP2D6HIF1A | |
| SCHEMBL15109016 | 0.79 | CHRNB4 (0.46) | KMT2AMEN1CHRM3 | |
| SCHEMBL3827917 | 0.78 | KCNA3 (0.31) | KMT2AMEN1CYP1A2CYP2D6HIF1A | |
| SCHEMBL17114344 | 0.77 | KDM4E (0.46) | KMT2AMEN1CYP1A2CYP2D6HIF1A | |
| SCHEMBL17114345 | 0.77 | KDM4E (0.46) | KMT2AMEN1CYP1A2CYP2D6HIF1A | |
| SCHEMBL4771389 | 0.75 | ALDH1A1 (0.46) | CYP1A2KDM4EALDH1A1 | |
| SCHEMBL25665529 | 0.74 | SLC6A9 (0.46) | KMT2AMEN1CYP1A2CYP2D6HIF1A | |
| SCHEMBL8534618 | 0.73 | OPRM1 (0.46) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL4848261 | 0.73 | KMT2A (0.43) | KMT2AKDM4EALDH1A1SPHK1SPHK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888572-A1 | QUINAZOLINES AND THEIR USE AS AURORA KINASE INHIBITORS | AstraZeneca AB (SE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006129064-A1 | QUINAZOLINES AND THEIR USE AS AURORA KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-12-07 | — | — | WO | disclosed |