Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.41 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | EPOR | P19235 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4369577 | 0.90 | SLC9A1 (0.43) | SLC9A1ALDH1A1HPGDLMNAMEN1 | |
| SCHEMBL27826145 | 0.80 | TRPM8 (0.46) | MEN1KMT2AEPORKDM4E | |
| SCHEMBL5652973 | 0.78 | PPARD (0.49) | ALDH1A1MAPTPOLB | |
| SCHEMBL5650478 | 0.78 | TRPM8 (0.50) | MEN1KMT2AMMP2MMP8MMP12 | |
| SCHEMBL2246642 | 0.77 | MMP12 (0.41) | ALDH1A1MAPTHPGDALOX5LMNA | |
| SCHEMBL4369489 | 0.76 | PTGES (0.45) | ALDH1A1MAPTHPGDALOX5LMNA | |
| SCHEMBL5652505 | 0.75 | KMT2A (0.40) | ALDH1A1TDP1LMNAMEN1KMT2A | |
| SCHEMBL5653525 | 0.75 | SRD5A2 (0.44) | ALOX5MEN1KMT2AFFAR1MMP12 | |
| SCHEMBL5651671 | 0.75 | OXTR (0.46) | — | |
| SCHEMBL4359337 | 0.74 | MMP12 (0.39) | ALDH1A1MAPTHPGDALOX5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902014-A2 | GLUTAMATE AGGRECANASE INHIBITORS | Wyeth (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007008994-A2 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2007-01-18 | — | — | WO | disclosed |