Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A1 | P19634 | 2/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 5/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 5/20 | 0.37 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | TSPO | P30536 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | EPOR | P19235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4621079 | 0.90 | SLC9A1 (0.42) | SLC9A1ALDH1A1HPGDLMNAMEN1 | |
| SCHEMBL4369489 | 0.76 | PTGES (0.45) | ALDH1A1HPGDLMNAMEN1KMT2A | |
| SCHEMBL27826145 | 0.75 | TRPM8 (0.46) | PPARGTSHRMEN1KMT2AEPOR | |
| SCHEMBL5650478 | 0.73 | TRPM8 (0.50) | HSD17B1HSD17B2PPARGMEN1KMT2A | |
| SCHEMBL2245137 | 0.72 | C3AR1 (0.53) | SLC9A1C3AR1 | |
| SCHEMBL2246642 | 0.72 | MMP12 (0.41) | ALDH1A1HPGDLMNA | |
| SCHEMBL5652973 | 0.71 | PPARD (0.49) | PSMB5ALDH1A1 | |
| SCHEMBL2247819 | 0.71 | HSD17B2 (0.42) | HSD17B1HSD17B2ALDH1A1HPGDPPARG | |
| SCHEMBL5652505 | 0.71 | KMT2A (0.40) | ALDH1A1PPARGLMNAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8630191 | 0.70 | MEN1 (0.44) | ALDH1A1HPGDPPARGLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7553873-B2 | Glutamate aggrecanase inhibitors | WYETH (US) | 2009-06-30 | — | — | US | disclosed |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | ADAMTS5, ADAMTS1, ADAMTS7 | SLC9A1 870/4885HSD17B1 2139/4885HSD17B2 2502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.