Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.44 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.44 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.40 |
| ▸ | PTPRC | P08575 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2246525 | 0.91 | NPC1 (0.43) | MAPK14NPC1RAB9AATMPTPRC | |
| SCHEMBL4621148 | 0.82 | MAPT (0.55) | MAPK14NPC1RAB9AATMPTPRC | |
| SCHEMBL2249427 | 0.80 | CA2 (0.59) | MAPK14NPC1RAB9AATMPTPRC | |
| SCHEMBL2248134 | 0.79 | POLB (0.52) | MAPK14NPC1RAB9AATMPTPRC | |
| SCHEMBL4623235 | 0.79 | RAB9A (0.43) | ACHEMAPK14NPC1RAB9AATM | |
| SCHEMBL2244945 | 0.79 | PTPRC (0.47) | MAPK14NPC1RAB9AATMPTPRC | |
| SCHEMBL3587576 | 0.76 | CCKBR (0.51) | — | |
| SCHEMBL10425308 | 0.75 | ALDH1A1 (0.56) | NPC1RAB9A | |
| SCHEMBL7350261 | 0.75 | NOD1 (0.49) | BCHEACHECACNA1FCACNA1DCACNA1S | |
| SCHEMBL8430970 | 0.75 | NOD1 (0.49) | BCHEACHECACNA1FCACNA1DCACNA1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902014-A2 | GLUTAMATE AGGRECANASE INHIBITORS | Wyeth (US) | 2008-03-26 | — | — | EP | claimed |
| WO-2007008994-A2 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2007-01-18 | — | — | WO | claimed |