SCHEMBL4621189

SCHEMBL4621189

CC(C)Oc1cc(Br)ccc1O[Si](C)(C)C(C)(C)C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APLNR P35414 2/20 0.39
HRH4 Q9H3N8 1/20 0.38
ALDH1A1 P00352 2/20 0.37
HTT P42858 2/20 0.37
LMNA P02545 1/20 0.37
POLB P06746 1/20 0.37
MAPT P10636 1/20 0.37
ALOX12 P18054 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
DRD2 P14416 1/20 0.33
AR P10275 1/20 0.33
GABRA1 P14867 1/20 0.33
GABRG2 P18507 1/20 0.33
GABRB3 P28472 1/20 0.33
GABRA5 P31644 1/20 0.33
GABRA3 P34903 1/20 0.33
MAPK1 P28482 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
LRRK2 Q5S007 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4816617 0.81 DRD2 (0.45) POLBSMN1; SMN2DRD2TDP1EDNRB
SCHEMBL4621217 0.79 DRD2 (0.33) DRD2
SCHEMBL13956545 0.79 APLNR (0.45) APLNRALDH1A1HTTSMN1; SMN2GABRA1
SCHEMBL17184765 0.79 APLNR (0.36) APLNRHTTPOLBDRD2TDP1
SCHEMBL941194 0.78 DRD2 (0.40) POLBSMN1; SMN2DRD2TDP1EDNRB
SCHEMBL30393256 0.76 RAB9A (0.43) APLNRALDH1A1LMNAPOLBMAPT
SCHEMBL2287094 0.76 RAB9A (0.43) APLNRALDH1A1LMNAPOLBMAPT
SCHEMBL15085977 0.76 APLNR (0.45) APLNRALDH1A1HTTMAPTMAPK1
SCHEMBL6940385 0.76 EDNRB (0.36) APLNRALDH1A1DRD2MAPK1TDP1
SCHEMBL131870 0.75 ALDH1A1 (0.46) HRH4ALDH1A1HTTLMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013016720-A2 NOVEL SUBSTITUTED BIARYLHETEROCYCLE DERIVATIVES AS PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER DISEASES GERINDA THERAPEUTICS, INC. (US) 2013-01-31 WO disclosed
EP-1896462-A2 SUBSTITUTED BIARYLHETEROCYCLE DERIVATIVES AS PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER DISEASES The Pfahl Family Trust (Dated 9 July 1996) (US) 2008-03-12 EP disclosed
WO-2006130613-A2 SUBSTITUTED BIARYLHETEROCYCLE DERIVATIVES AS PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND OTHER DISEASES THE PFAHL FAMILY TRUST (DATED 9 JULY 1996) (US) 2006-12-07 WO disclosed