SCHEMBL462140

SCHEMBL462140

CSc1c(C)c(C(=O)O)cc(C2=CC(=O)C3CCC2C3)c1C(F)(F)C(F)(F)F

nearest known ligand 0.30

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ADRB3 P13945 1/20 0.30
ADRA2B P18089 1/20 0.30
DRD1 P21728 1/20 0.30
DRD5 P21918 1/20 0.30
ADRA1B P35368 1/20 0.30
P2RY14 Q15391 1/20 0.30
TMEM97 Q5BJF2 1/20 0.30
SIGMAR1 Q99720 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL420552 0.71
SCHEMBL419198 0.62 TAS2R14 (0.35)
SCHEMBL17395289 0.59 GPR35 (0.41)
SCHEMBL416274 0.56 CFTR (0.38)
SCHEMBL27733843 0.55 MAPT (0.50) ADRB3ADRA2BDRD1DRD5ADRA1B
SCHEMBL21241026 0.55 MAPT (0.46)
SCHEMBL412257 0.55 TAS2R14 (0.42)
SCHEMBL28007554 0.53 MAPT (0.44)
SCHEMBL28007551 0.53 MAPT (0.44)
SCHEMBL16762134 0.53 TAS2R14 (0.40) ADRB3ADRA2BDRD1DRD5ADRA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2595955-B1 (4-HALOGENALKYL-3-THIOBENZOYL)CYCLOHEXANEDIONES AND USE THEREOF AS HERBICIDES BAYER IP GMBH (DE) 2016-11-30 EP disclosed
EP-2595955-A1 (4-HALOGENALKYL-3-THIOBENZOYL)CYCLOHEXANEDIONES AND USE THEREOF AS HERBICIDES Bayer Intellectual Property GmbH (DE) 2013-05-29 EP disclosed
WO-2012010575-A1 (4-HALOGENALKYL-3-THIOBENZOYL)CYCLOHEXANEDIONES AND USE THEREOF AS HERBICIDES BAYER CROPSCIENCE AG (DE) 2012-01-26 WO disclosed