Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 2/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 3/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4621100 | 0.86 | KDM4E (0.43) | CASP3PLA2G2AKDM4EHSD17B10IDO1 | |
| SCHEMBL4621102 | 0.84 | PLA2G2A (0.42) | CASP3PLA2G2AKDM4EHSD17B10IDO1 | |
| SCHEMBL4648307 | 0.82 | IDO1 (0.41) | IDO1GAADHODHMEN1HPGD | |
| SCHEMBL4621639 | 0.73 | PDE10A (0.47) | CASP3KDM4EIDO1PRNPGAA | |
| SCHEMBL4621105 | 0.72 | GAA (0.40) | CASP3KDM4EHSD17B10PRNPGAA | |
| SCHEMBL14255182 | 0.72 | PLA2G2A (0.41) | CASP3PLA2G2AKDM4EHSD17B10IDO1 | |
| SCHEMBL4622564 | 0.69 | KDM4E (0.37) | CASP3PLA2G2AKDM4EHSD17B10IDO1 | |
| SCHEMBL5093369 | 0.68 | PLA2G2A (0.45) | CASP3PLA2G2AKDM4EHSD17B10IDO1 | |
| SCHEMBL4621671 | 0.68 | PLA2G2A (0.45) | CASP3PLA2G2AKDM4EHSD17B10IDO1 | |
| SCHEMBL4621944 | 0.67 | MEN1 (0.44) | MEN1KMT2ACYP1A2CYP2C19PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696924-B1 | ACIDIC QUINOLINE DERIVATIVES AND THEIR USE FOR THE PREVENTION AND/OR TREATMENT OF HYPERGLYCAEMIA-RELATED PATHOLOGIES | MERCK PATENT GMBH (DE) | 2008-03-26 | — | — | EP | claimed |