Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 2/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4622162 | 0.86 | CASP3 (0.39) | KDM4EHSD17B10CASP3PLA2G2APRNP | |
| SCHEMBL4621671 | 0.81 | PLA2G2A (0.45) | KDM4EHSD17B10CASP3PLA2G2APRNP | |
| SCHEMBL4649127 | 0.78 | ALOX15 (0.42) | KDM4EHSD17B10DHODHIDO1PDE10A | |
| SCHEMBL5093369 | 0.77 | PLA2G2A (0.45) | KDM4EHSD17B10CASP3PLA2G2APRNP | |
| SCHEMBL4621639 | 0.76 | PDE10A (0.47) | KDM4ECASP3PRNPDHODHIDO1 | |
| SCHEMBL14255061 | 0.75 | KDM4E (0.38) | KDM4EHSD17B10CASP3PLA2G2ADHODH | |
| SCHEMBL5097600 | 0.73 | ALOX15 (0.42) | KDM4EHSD17B10DHODHIDO1PDE10A | |
| SCHEMBL4622564 | 0.71 | KDM4E (0.37) | KDM4EHSD17B10CASP3PLA2G2APRNP | |
| SCHEMBL5092051 | 0.71 | PLA2G2A (0.44) | KDM4EHSD17B10CASP3PLA2G2APRNP | |
| SCHEMBL5090593 | 0.70 | PLA2G2A (0.46) | KDM4EHSD17B10PLA2G2ADHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696924-B1 | ACIDIC QUINOLINE DERIVATIVES AND THEIR USE FOR THE PREVENTION AND/OR TREATMENT OF HYPERGLYCAEMIA-RELATED PATHOLOGIES | MERCK PATENT GMBH (DE) | 2008-03-26 | — | — | EP | claimed |