Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 3/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4621102 | 0.90 | PLA2G2A (0.42) | IDO1DHODH | |
| SCHEMBL4622162 | 0.82 | CASP3 (0.39) | IDO1PDE10AMEN1GAAHPGD | |
| SCHEMBL4649127 | 0.82 | ALOX15 (0.42) | IDO1ALDH1A1ALOX15NR1H4PDE10A | |
| SCHEMBL5097600 | 0.82 | ALOX15 (0.42) | IDO1ALDH1A1ALOX15NR1H4PDE10A | |
| SCHEMBL4620763 | 0.81 | PDE10A (0.52) | IDO1ALDH1A1ALOX15NR1H4PDE10A | |
| SCHEMBL4620342 | 0.78 | ALOX15 (0.43) | IDO1ALDH1A1ALOX15PDE10AGAA | |
| SCHEMBL4620353 | 0.78 | ALOX15 (0.43) | IDO1ALDH1A1ALOX15PDE10AGAA | |
| SCHEMBL4621105 | 0.77 | GAA (0.40) | ALDH1A1PDE10AMEN1GAAHPGD | |
| SCHEMBL5088569 | 0.77 | DHODH (0.45) | IDO1ALDH1A1ALOX15PDE10AHPGD | |
| SCHEMBL14255182 | 0.77 | PLA2G2A (0.41) | IDO1ALOX15MEN1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696924-B1 | ACIDIC QUINOLINE DERIVATIVES AND THEIR USE FOR THE PREVENTION AND/OR TREATMENT OF HYPERGLYCAEMIA-RELATED PATHOLOGIES | MERCK PATENT GMBH (DE) | 2008-03-26 | — | — | EP | claimed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| US-7470708-B2 | Acidic quinoline derivatives and their use for the prevention and/or treatment of hyperglycaemia-related pathologies | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2008-12-30 | — | — | US | disclosed |
| EP-1696924-A1 | ACIDIC QUINOLINE DERIVATIVES AND THEIR USE FOR THE PREVENTION AND/OR TREATMENT OF HYPERGLYCAEMIA-RELATED PATHOLOGIES | MERCK PATENT GmbH (DE) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005063244-A1 | ACIDIC QUINOLINE DERIVATIVES AND THEIR USE FOR THE PREVENTION AND/OR TREATMENT OF HYPERGLYCAEMIA-RELATED PATHOLOGIES | MERCK PATENT GMBH (DE) | 2005-07-14 | — | — | WO | disclosed |