Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | ICMT | O60725 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4621639 | 0.84 | PDE10A (0.47) | KDM4ECASP3ALDH1A1HPGDPDE10A | |
| SCHEMBL4621902 | 0.83 | ALOX15 (0.42) | KDM4EALDH1A1CYP3A4HPGDMAPK1 | |
| SCHEMBL4622456 | 0.82 | ALDH1A1 (0.37) | CASP3ALDH1A1PLA2G2APDE10AIDO1 | |
| SCHEMBL5704026 | 0.81 | ALDH1A1 (0.40) | KDM4EALDH1A1CYP3A4HPGDMAPK1 | |
| SCHEMBL5704033 | 0.81 | ALDH1A1 (0.40) | KDM4EALDH1A1CYP3A4HPGDMAPK1 | |
| SCHEMBL5098641 | 0.81 | PLA2G2A (0.43) | KDM4ECASP3HPGDPLA2G2APTGES | |
| SCHEMBL4621944 | 0.76 | MEN1 (0.44) | ALDH1A1CYP3A4PDE10A | |
| SCHEMBL4621100 | 0.71 | KDM4E (0.43) | KDM4ECASP3PLA2G2APDE10AIDO1 | |
| SCHEMBL5704029 | 0.71 | ALDH1A1 (0.32) | ALDH1A1PLA2G2APDE10AIDO1 | |
| SCHEMBL28948158 | 0.71 | HPGD (0.45) | KDM4EALDH1A1CYP3A4HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696924-B1 | ACIDIC QUINOLINE DERIVATIVES AND THEIR USE FOR THE PREVENTION AND/OR TREATMENT OF HYPERGLYCAEMIA-RELATED PATHOLOGIES | MERCK PATENT GMBH (DE) | 2008-03-26 | — | — | EP | claimed |